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一种新型苯甲醛衍生物对……表现出抗黄曲霉毒素生成活性。

A New Benzaldehyde Derivative Exhibits Antiaflatoxigenic Activity against .

作者信息

Jermnak Usuma, Ngernmeesri Paiboon, Yurayart Chompoonek, Poapolathep Amnart, Udomkusonsri Pareeya, Poapolathep Saranya, Phaochoosak Napasorn

机构信息

Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.

出版信息

J Fungi (Basel). 2023 Nov 12;9(11):1103. doi: 10.3390/jof9111103.

DOI:10.3390/jof9111103
PMID:37998908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10672374/
Abstract

Aflatoxin B1 (AFB1) is the most potent naturally occurring carcinogen for humans and animals produced by the common fungus (). Aflatoxin (AF) contamination in commodities is a global concern related to the safety of food and feed, and it also impacts the agricultural economy. In this study, we investigated the AFB1-inhibiting activity of a new benzaldehyde derivative, 2-[(2-methylpyridin-3-yl)oxy]benzaldehyde (MPOBA), on It was found that MPOBA inhibited the production of AFB1 by , with an IC value of 0.55 mM. Moreover, the inhibition of conidiation was also observed at the same concentration. The addition of MPOBA resulted in decreased transcript levels of the gene, which encodes a key regulatory protein for the biosynthesis of AF, and also decreased transcript levels of the global regulator genes and . These results suggested that MPOBA has an effect on the regulatory mechanism of the development and differentiation of conidia, leading to the inhibition of AFB1 production. In addition, the cytotoxicity study showed that MPOBA had a very low cytotoxic effect on the Madin-Darby canine kidney (MDCK) cell line. Therefore, MPOBA may be a potential compound for developing practically effective agents to control AF contamination.

摘要

黄曲霉毒素B1（AFB1）是由常见真菌产生的对人类和动物最具致癌性的天然致癌物。商品中的黄曲霉毒素（AF）污染是一个与食品和饲料安全相关的全球问题，同时也影响农业经济。在本研究中，我们研究了一种新型苯甲醛衍生物2-[(2-甲基吡啶-3-基)氧基]苯甲醛（MPOBA）对[具体内容缺失]的AFB1抑制活性。结果发现，MPOBA可抑制[具体内容缺失]产生AFB1，其IC值为0.55 mM。此外，在相同浓度下还观察到分生孢子形成受到抑制。添加MPOBA导致编码AF生物合成关键调节蛋白的[具体基因缺失]基因转录水平降低，同时也降低了全局调节基因[具体基因缺失]和[具体基因缺失]的转录水平。这些结果表明，MPOBA对分生孢子的发育和分化调节机制有影响，从而导致AFB1产生受到抑制。此外，细胞毒性研究表明，MPOBA对马德堡-达比犬肾（MDCK）细胞系的细胞毒性非常低。因此，MPOBA可能是开发实际有效的控制AF污染药物的潜在化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/c0e704309a46/jof-09-01103-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/7f2337f836b2/jof-09-01103-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/7541e4d4930c/jof-09-01103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/eb4027b5ab46/jof-09-01103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/ce83351e17f3/jof-09-01103-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/40212f714358/jof-09-01103-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/c0e704309a46/jof-09-01103-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/7f2337f836b2/jof-09-01103-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/7541e4d4930c/jof-09-01103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/eb4027b5ab46/jof-09-01103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/ce83351e17f3/jof-09-01103-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/40212f714358/jof-09-01103-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfb/10672374/c0e704309a46/jof-09-01103-g005.jpg

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本文引用的文献

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Toxins (Basel). 2023 Mar 28;15(4):246. doi: 10.3390/toxins15040246.
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Upstream Regulation of Development and Secondary Metabolism in Species.物种发育和次生代谢的上游调控。
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New Insights of Transcriptional Regulator AflR in Aspergillus flavus Physiology.转录调控因子 AflR 在黄曲霉生理中的新见解。
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Evaluation of Benzaldehyde as an Antibiotic Modulator and Its Toxic Effect against .评估苯甲醛作为一种抗生素调节剂及其对. 的毒性作用。
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Toxins (Basel). 2021 Mar 12;13(3):204. doi: 10.3390/toxins13030204.
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Biological Control and Mitigation of Aflatoxin Contamination in Commodities.生物防治与商品中黄曲霉毒素污染的缓解
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