McLean T R, Bombeck C T, Nyhus L M
Am J Surg. 1987 Jan;153(1):91-5. doi: 10.1016/0002-9610(87)90207-8.
Although an absolute correlation has been impossible to demonstrate, it has long been thought that the manometric magnitude of the lower esophageal sphincter pressure was a good index of lower esophageal sphincter strength, and hence its competence. To study this relationship, 12 adult mongrel cats were surgically fitted with gastric cannulas. The cats were studied by six-lumen, radially-oriented, rapid pullback manometry before and after administration of atropine, and before and after daily perfusion of the distal esophagus with 0.1 N hydrochloric acid. Lower esophageal sphincter strength was determined by the lower esophageal sphincter pressure vector cross-sectional area. This was computed by plotting the lower esophageal sphincter pressure on polar coordinates, and finding the area circumscribed by the vectors. Lower esophageal sphincter competence was determined by measurement of both the intragastric volume and intragastric pressure required to produce gross reflux. Atropine significantly decreased the mean lower esophageal sphincter pressure vector cross-sectional area from 7,963 +/- 2,469 mm Hg to 720 +/- 59 mm Hg (p less than 0.05) and decreased the mean lower esophageal sphincter opening pressure from 30.2 +/- 6.9 mm Hg to 13.2 +/- 4.1 mm Hg (p less than 0.05). However, acid perfusion significantly decreased the lower esophageal sphincter pressure vector cross-sectional area from 6,786 +/- 3,334 mm Hg to 715 +/- 720 mm Hg (p less than 0.05). This indicates that the lower esophageal sphincter has two components, one of which is acid-sensitive and both of which are atropine-sensitive.
尽管一直无法证明存在绝对的相关性，但长期以来人们一直认为，食管下括约肌压力的测压值是食管下括约肌强度以及其功能的良好指标。为了研究这种关系，对12只成年杂种猫进行手术植入胃插管。在给予阿托品前后以及每天用0.1N盐酸灌注食管远端前后，通过六腔、径向取向、快速回撤测压法对猫进行研究。食管下括约肌强度由食管下括约肌压力矢量截面积确定。这是通过在极坐标上绘制食管下括约肌压力并找到矢量所围成的面积来计算的。食管下括约肌功能通过测量产生明显反流所需的胃内体积和胃内压力来确定。阿托品使平均食管下括约肌压力矢量截面积从7963±2469mmHg显著降至720±59mmHg（p<0.05），并使平均食管下括约肌开放压力从30.2±6.9mmHg降至13.2±4.1mmHg（p<0.05）。然而，酸灌注使食管下括约肌压力矢量截面积从6786±3334mmHg显著降至715±720mmHg（p<0.05）。这表明食管下括约肌有两个组成部分，其中一个对酸敏感，两个都对阿托品敏感。
