Nealon W H, Beauchamp R D, Townsend C M, Thompson J C
Am J Surg. 1987 Jan;153(1):96-101. doi: 10.1016/0002-9610(87)90208-x.
The role of cholecystokinin in bombesin-stimulated pancreatic secretion in dogs was examined by the use of a specific cholecystokinin antagonist, proglumide. The primary component of bombesin-stimulated pancreatic secretion at the lowest tested dose was due to cholecystokinin, with only 25 percent of bombesin-stimulated protein output preserved during proglumide infusion. Maximal stimulation of cholecystokinin release was achieved by even the lowest dose of bombesin, whereas dose-related increases in bombesin-stimulated protein secretion were observed. This increase in exocrine secretion is probably explained by increased direct bombesin stimulation. Our findings suggest that the maximal dose of bombesin is lower for cholecystokinin release than its effective dose for enzyme secretion. We conclude that, in all probability, postprandial release of bombesin (or its analogue, gastrin-releasing peptide) affects pancreatic function primarily through release of cholecystokinin.
通过使用一种特异性胆囊收缩素拮抗剂丙谷胺，研究了胆囊收缩素在蛙皮素刺激犬胰腺分泌中的作用。在最低测试剂量下，蛙皮素刺激胰腺分泌的主要成分是胆囊收缩素，在输注丙谷胺期间，蛙皮素刺激的蛋白质分泌量仅保留25%。即使是最低剂量的蛙皮素也能实现胆囊收缩素释放的最大刺激，而观察到蛙皮素刺激的蛋白质分泌呈剂量相关增加。这种外分泌增加可能是由于蛙皮素直接刺激增加所致。我们的研究结果表明，蛙皮素释放胆囊收缩素的最大剂量低于其刺激酶分泌的有效剂量。我们得出结论，餐后蛙皮素（或其类似物，胃泌素释放肽）的释放很可能主要通过胆囊收缩素的释放来影响胰腺功能。
