Lopes-Ferreira Monica, Farinha Luiz Rogério Ludwig, Costa Yasmin Stefanie Oliveira, Pinto Felipe Justiniano, Disner Geonildo Rodrigo, da Rosa João Gabriel Dos Santos, Lima Carla
Immunoregulation Unit, Laboratory of Applied Toxinology (CeTICs/FAPESP), Butantan Institute, São Paulo 05503900, Brazil.
Toxics. 2023 Oct 31;11(11):896. doi: 10.3390/toxics11110896.
The increasing number of studies reporting the risks of the exposure to pesticides aligned with the intensified use of such hazardous chemicals has emerged as a pressing contemporary issue, notably due to the potential effects to both the environment and human health. Pesticides, while broadly applied in modern agriculture for pest control and crop protection, have raised concerns due to their unintended effects on non-target organisms. The immune system exerts a key role in the protection against the exposome, which could result in cellular imbalances and tissue damage through the inflammatory response. Pesticides, which encompass a diverse array of chemicals, have been linked to inflammation in experimental models. Therefore, the aim of this review is to discuss the increasing concern over the risks of pesticide exposure focusing on the effects of various chemical classes on inflammation by covering, as broadly as possible, different experimental approaches as well as the multiple or co-exposure of pesticides. Overall, pesticides potentially induce inflammation in different experimental models, manifested through skin irritation, respiratory impairment, or systemic effects. The connection between pesticides and inflammation highlights the importance of proper handling and regulation of these substances and underscores the need for research into safer and sustainable practices to reduce our reliance on synthetic pesticides and fertilizers.
随着农药这种危险化学品的使用日益强化，报告农药接触风险的研究数量不断增加，这已成为一个紧迫的当代问题，尤其是考虑到其对环境和人类健康的潜在影响。农药虽然广泛应用于现代农业以控制害虫和保护作物，但因其对非目标生物的意外影响而引发了关注。免疫系统在抵御暴露组方面发挥着关键作用，暴露组可能通过炎症反应导致细胞失衡和组织损伤。农药包含各种各样的化学物质，在实验模型中已与炎症相关联。因此，本综述的目的是讨论对农药接触风险日益增加的关注，重点是各类化学物质对炎症的影响，尽可能广泛地涵盖不同的实验方法以及农药的多重或共同接触。总体而言，农药在不同实验模型中可能诱发炎症，表现为皮肤刺激、呼吸功能损害或全身影响。农药与炎症之间的联系凸显了妥善处理和监管这些物质的重要性，并强调需要研究更安全和可持续的做法，以减少我们对合成农药和化肥的依赖。
