Psychiatry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Clinical Hematology Unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, Al-Sharika, Zagazig, 44519, Egypt.
Psychopharmacology (Berl). 2024 Feb;241(2):351-357. doi: 10.1007/s00213-023-06491-8. Epub 2023 Nov 24.
Immune dysfunction and inflammation participate in the pathophysiology of bipolar disorder (BD). Abnormal levels of inflammatory markers, namely, red cell distribution width (RDW) and platelet distribution width (PDW), were detected in BD. Electroconvulsive therapy (ECT) for various mental disorders including BD was linked to changes in these inflammatory mediators. Hence, we aimed to assess the impact of ECT on PDW and RDW in patients with BD.
Seventy-two patients aged ≥ 16 were enrolled in the current prospective cohort study over 6 months, diagnosed as BD based on DSM-IV and indicated for ECT and complete blood count (CBC) drawn pre-ECT and after four ECT sessions.
By the end of the ECT sessions, we noticed a significant elevation in PDW with lowering in RDW levels. However, no significant differences were detected before and after ECT regarding platelet (PLTs) count, mean platelet volume (MPV), and Plateletcrit (PCT).
ECT seems to improve the CBC-derived inflammatory markers (RDW and PDW) subsequently, improving the underlying inflammatory process in BD without disturbing PLT homeostasis which support its anti-inflammatory role in BD.
免疫功能障碍和炎症参与双相情感障碍（BD）的病理生理学。BD 患者存在炎症标志物水平异常，即红细胞分布宽度（RDW）和血小板分布宽度（PDW）升高。电抽搐治疗（ECT）用于治疗包括 BD 在内的各种精神障碍，与这些炎症介质的变化有关。因此，我们旨在评估 ECT 对 BD 患者 PDW 和 RDW 的影响。
本前瞻性队列研究在 6 个月内纳入了 72 名年龄≥16 岁的患者，根据 DSM-IV 诊断为 BD，指征为 ECT 和 ECT 前和 4 次 ECT 后采集的全血细胞计数（CBC）。
ECT 疗程结束时，PDW 显著升高，RDW 水平降低。然而，ECT 前后血小板（PLTs）计数、平均血小板体积（MPV）和血小板比容（PCT）无显著差异。
ECT 似乎随后改善了基于 CBC 的炎症标志物（RDW 和 PDW），改善了 BD 中的潜在炎症过程，而不干扰 PLT 稳态，这支持其在 BD 中的抗炎作用。
