HHMI Janelia Research Campus, 19700 Helix Drive, Ashburn, VA, 20147, USA.
Nat Commun. 2023 Nov 24;14(1):7693. doi: 10.1038/s41467-023-43566-8.
Color and motion are used by many species to identify salient objects. They are processed largely independently, but color contributes to motion processing in humans, for example, enabling moving colored objects to be detected when their luminance matches the background. Here, we demonstrate an unexpected, additional contribution of color to motion vision in Drosophila. We show that behavioral ON-motion responses are more sensitive to UV than for OFF-motion, and we identify cellular pathways connecting UV-sensitive R7 photoreceptors to ON and OFF-motion-sensitive T4 and T5 cells, using neurogenetics and calcium imaging. Remarkably, this contribution of color circuitry to motion vision enhances the detection of approaching UV discs, but not green discs with the same chromatic contrast, and we show how this could generalize for systems with ON- and OFF-motion pathways. Our results provide a computational and circuit basis for how color enhances motion vision to favor the detection of saliently colored objects.
颜色和运动被许多物种用于识别显著物体。它们在很大程度上是独立处理的，但颜色对人类的运动处理有贡献，例如，当运动的彩色物体的亮度与背景相匹配时，它们可以被检测到。在这里，我们证明了颜色对果蝇运动视觉的一个意想不到的额外贡献。我们表明，行为上的 ON 运动反应对 UV 比 OFF 运动更敏感，我们使用神经遗传学和钙成像来识别连接 UV 敏感的 R7 光感受器与 ON 和 OFF 运动敏感的 T4 和 T5 细胞的细胞途径。值得注意的是，这种颜色电路对运动视觉的贡献增强了对接近的 UV 圆盘的检测，但对具有相同色度对比度的绿色圆盘则没有，我们展示了这如何推广到具有 ON 和 OFF 运动途径的系统。我们的研究结果为颜色如何增强运动视觉以有利于检测显著颜色物体提供了一个计算和电路基础。
