Reproductive Center Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 1617 Riyue Avenue, Chengdu, 611731, Sichuan, China.
Reprod Biol Endocrinol. 2023 Nov 24;21(1):112. doi: 10.1186/s12958-023-01164-9.
This study aimed to assess the predictive value of endometrial blood flow branches on pregnancy outcomes after hormone replacement therapy-frozen embryo transfer (HRT-FET).
This prospective observational study involved 292 reproductive-aged women who underwent endometrial receptivity assessment in a tertiary care academic medical center in southwest China using power Doppler ultrasonography during HRT-FET. Three-dimensional power Doppler ultrasound was performed on the day of endometrial transformation and the day before embryo transfer. The endometrial blood flow branches of the endometrial and subendometrial regions were compared in the non-pregnant and pregnant groups at the two time points mentioned above.
The endometrial blood flow branches were higher in pregnant patients than in non-pregnant patients on the day of endometrial transformation (P = 0.009) and the day before embryo transfer (P = 0.001). Changes in endometrial blood flow pattern and endometrial blood flow branches at the two time points did not differ among the pregnancy outcome samples. After adjusting for age, antral follicles, and embryos transferred, the endometrial blood flow branches on the day before embryo transfer was the independent factor influencing the chance of clinical pregnancy, with an odds ratio of 3.001 (95% confidence interval: 1.448 - 6.219, P = 0.003).
Endometrial blood flow perfusion during the peri-transplantation period of the HRT-FET cycle is a good indicator of pregnancy outcomes, suggesting that valuation of endometrial branches via power Doppler ultrasound is a simple and effective approach for achieving indicator measurements.
本研究旨在评估激素替代治疗-冻融胚胎移植(HRT-FET)后子宫内膜血流分支对妊娠结局的预测价值。
本前瞻性观察研究纳入了 292 名在中国西南部一家三级学术医疗中心接受 HRT-FET 的生育期妇女,在 HRT-FET 期间使用能量多普勒超声进行子宫内膜容受性评估。在子宫内膜转化日和胚胎移植前一天进行三维能量多普勒超声检查。比较上述两个时间点非妊娠和妊娠组的子宫内膜和子宫下段区域的子宫内膜血流分支。
在子宫内膜转化日(P=0.009)和胚胎移植前一天(P=0.001),妊娠患者的子宫内膜血流分支高于非妊娠患者。在两个时间点,妊娠结局样本中子宫内膜血流模式和子宫内膜血流分支的变化没有差异。在校正年龄、窦卵泡数和移植胚胎数后,胚胎移植前一天的子宫内膜血流分支是影响临床妊娠机会的独立因素,优势比为 3.001(95%置信区间:1.448-6.219,P=0.003)。
HRT-FET 周期移植期间的子宫内膜血流灌注是妊娠结局的良好指标,提示通过能量多普勒超声评估子宫内膜分支是一种简单有效的指标测量方法。