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伴先兆偏头痛患者P100波潜伏期过早的前瞻性配对病例对照研究

Prospective Matched Case-Control Study of Over-Early P100 Wave Latency in Migraine with Aura.

作者信息

Alshamrani Foziah J, AlSheikh Mona Hmoud, Almuslim Noora, Al Azman Hatem, Alkhamis Fahad, Nazish Saima, Alnajashi Hind, Alsulaiman Abdulla

机构信息

Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.

Physiology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.

出版信息

Biomedicines. 2023 Nov 6;11(11):2979. doi: 10.3390/biomedicines11112979.

Abstract

A sizable portion of the world's population suffers from migraines with aura. The purpose of this research is to describe the findings of a case-control study that was carried out to gain a better understanding of how migraine with aura manifests. The research looked at the P100 delay of the visual-evoked potential in both eyes of 92 healthy people and 44 patients who suffered from migraines with visual aura. All of the participants in the study were recruited from King Fahad University Hospital in Saudi Arabia. Both sets of people had the same ancestry and originated from the same location. Patients who suffered from migraines with aura exhibited a significantly shorter P100 delay in both eyes compared to healthy controls ( = 0.001), which is evidence that their early visual processing was distinct. In order to arrive at these findings, we compared people who suffer from migraines with aura to people who do not suffer from migraines and used them as subjects. These findings contribute to the ongoing attempts to bring the disease under control and provide vitally significant new information regarding the functioning of headaches with auras. The primary focus of study in the future should be on determining the nature of the connection between issues with early visual processing and headaches with aura.

摘要

世界上有相当一部分人口患有伴有先兆的偏头痛。本研究的目的是描述一项病例对照研究的结果,该研究旨在更好地了解伴有先兆的偏头痛是如何表现的。该研究观察了92名健康人和44名患有视觉先兆偏头痛患者双眼的视觉诱发电位P100潜伏期。研究中的所有参与者均招募自沙特阿拉伯法赫德国王大学医院。两组人群有相同的血统且来自同一地区。与健康对照组相比,患有先兆偏头痛的患者双眼的P100潜伏期显著缩短(P = 0.001),这证明他们的早期视觉处理存在差异。为了得出这些结果,我们将患有先兆偏头痛的人与未患偏头痛的人进行比较,并将他们作为研究对象。这些发现有助于当前控制该疾病的努力,并提供了关于伴有先兆头痛发作机制的极其重要的新信息。未来研究的主要重点应是确定早期视觉处理问题与伴有先兆头痛之间联系的本质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e0a/10669729/63b23d37df3f/biomedicines-11-02979-g001.jpg

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