颅内动脉瘤与脂代谢紊乱:从分子机制到临床意义。
Intracranial Aneurysms and Lipid Metabolism Disorders: From Molecular Mechanisms to Clinical Implications.
机构信息
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200090, China.
Neurosurgical Institute, Fudan University, Shanghai 200032, China.
出版信息
Biomolecules. 2023 Nov 14;13(11):1652. doi: 10.3390/biom13111652.
Many vascular diseases are linked to lipid metabolism disorders, which cause lipid accumulation and peroxidation in the vascular wall. These processes lead to degenerative changes in the vessel, such as phenotypic transformation of smooth muscle cells and dysfunction and apoptosis of endothelial cells. In intracranial aneurysms, the coexistence of lipid plaques is often observed, indicating localized lipid metabolism disorders. These disorders may impair the function of the vascular wall or result from it. We summarize the literature on the relationship between lipid metabolism disorders and intracranial aneurysms below.
许多血管疾病都与脂质代谢紊乱有关,脂质代谢紊乱会导致血管壁中的脂质积累和过氧化。这些过程导致血管发生退行性变化,如平滑肌细胞表型转化、内皮细胞功能障碍和凋亡。在颅内动脉瘤中,常观察到脂质斑块共存,表明局部脂质代谢紊乱。这些紊乱可能损害血管壁的功能,也可能是由其引起的。我们总结了以下关于脂质代谢紊乱与颅内动脉瘤关系的文献。