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脂蛋白(a)：作为心血管疾病因果风险因素的证据及新兴疗法

Lipoprotein(a): Evidence for Role as a Causal Risk Factor in Cardiovascular Disease and Emerging Therapies.

作者信息

Bhatia Harpreet S, Wilkinson Michael J

机构信息

Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

出版信息

J Clin Med. 2022 Oct 13;11(20):6040. doi: 10.3390/jcm11206040.

DOI:10.3390/jcm11206040
PMID:36294361
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9604626/
Abstract

Lipoprotein(a) (Lp(a)) is an established risk factor for multiple cardiovascular diseases. Several lines of evidence including mechanistic, epidemiologic, and genetic studies support the role of Lp(a) as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis/calcific aortic valve disease (AS/CAVD). Limited therapies currently exist for the management of risk associated with elevated Lp(a), but several targeted therapies are currently in various stages of clinical development. In this review, we detail evidence supporting Lp(a) as a causal risk factor for ASCVD and AS/CAVD, and discuss approaches to managing Lp(a)-associated risk.

摘要

脂蛋白(a) [Lp(a)] 是多种心血管疾病公认的危险因素。包括机制研究、流行病学研究和遗传学研究在内的多项证据支持Lp(a) 作为动脉粥样硬化性心血管疾病（ASCVD）和主动脉瓣狭窄/钙化性主动脉瓣疾病（AS/CAVD）的因果危险因素所起的作用。目前针对与Lp(a) 升高相关风险的管理疗法有限，但几种靶向疗法目前正处于临床开发的不同阶段。在本综述中，我们详细阐述了支持Lp(a) 作为ASCVD和AS/CAVD因果危险因素的证据，并讨论了管理Lp(a) 相关风险的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09de/9604626/0ac18d0cb54c/jcm-11-06040-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09de/9604626/51d4b2c030af/jcm-11-06040-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09de/9604626/0ac18d0cb54c/jcm-11-06040-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09de/9604626/51d4b2c030af/jcm-11-06040-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09de/9604626/0ac18d0cb54c/jcm-11-06040-g002.jpg

相似文献

[1]
Lipoprotein(a): Evidence for Role as a Causal Risk Factor in Cardiovascular Disease and Emerging Therapies.

J Clin Med. 2022-10-13

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Demographics of lipoprotein(a) and stroke: The UK biobank.

Am J Prev Cardiol. 2025-6-29

[2]
Cardiovascular Implications of Lipoprotein(a) and its Genetic Variants: A Critical Review From the Middle East.

JACC Asia. 2025-7

[3]
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Curr Cardiol Rep. 2025-6-25

[4]
Peripheral arterial disease associated with elevated lipoprotein(a): a review of the evidence and treatment approaches.

Curr Opin Lipidol. 2025-5-26

[5]
Small interfering RNA effect on lipoprotein(a): a systematic review.

Egypt Heart J. 2025-5-8

[6]
Lipoprotein(a) and Atrial Fibrillation: Mechanistic Insights and Therapeutic Approaches.

Int J Med Sci. 2025-1-1

[7]
Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol-Mediated Cardiovascular Risk: A Participant-Level Meta-Analysis.

Circulation. 2025-1-28

[8]
Strategies for management of patients with elevated lipoprotein(a).

Curr Opin Lipidol. 2024-10-1

[9]
Lipoprotein(a) as a cardiovascular risk factor among patients with and without diabetes Mellitus: the Mass General Brigham Lp(a) Registry.

Cardiovasc Diabetol. 2024-7-18

[10]
-: Understanding Our Diversity and Disparities in Lp(a) Screening.

JACC Adv. 2024-5-1

本文引用的文献

[1]
Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes.

J Am Coll Cardiol. 2022-10-4

[2]
Lipoprotein(a) and the Risk for Coronary Heart Disease and Ischemic Stroke Events Among Black and White Adults With Cardiovascular Disease.

J Am Heart Assoc. 2022-6-7

[3]
Non-genetic influences on lipoprotein(a) concentrations.

Atherosclerosis. 2022-5

[4]
Cascade testing for elevated lipoprotein(a) in relatives of probands with high lipoprotein(a).

Am J Prev Cardiol. 2022-4-21

[5]
How Do Lipoprotein(a) Concentrations Affect Clinical Outcomes for Patients With Stable Coronary Artery Disease Who Underwent Different Dual Antiplatelet Therapy After Percutaneous Coronary Intervention?

J Am Heart Assoc. 2022-5-3

[6]
Elevated lipoprotein (a) levels and risk of peripheral artery disease outcomes: A systematic review.

Vasc Med. 2022-8

[7]
Elevated Lipoprotein(a) and Risk of Atrial Fibrillation: An Observational and Mendelian Randomization Study.

J Am Coll Cardiol. 2022-4-26

[8]
Lipoprotein(a), Menopausal Hormone Therapy, and Risk of Coronary Heart Disease in Postmenopausal Individuals.

JAMA Cardiol. 2022-5-1

[9]
Single Ascending Dose Study of a Short Interfering RNA Targeting Lipoprotein(a) Production in Individuals With Elevated Plasma Lipoprotein(a) Levels.

JAMA. 2022-5-3

[10]
Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a).

Nat Med. 2022-1

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