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无症状性主髂动脉瘤血管内治疗中的挑战应对:一项10年的比较分析

Navigating Challenges in the Endovascular Treatment of Asymptomatic Aortoiliac Aneurysms: A 10-Year Comparative Analysis.

作者信息

Chinsakchai Khamin, Ketklin Natcha, Hongku Kiattisak, Wongwanit Chumpol, Puangpunngam Nattawut, Hahtapornsawan Suteekhanit, Thongsai Sasima, Prapassaro Tossapol, Sermsathanasawadi Nuttawut, Ruangsetakit Chanean, Mutirangura Pramook

机构信息

Division of Vascular Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

出版信息

J Clin Med. 2023 Nov 9;12(22):7000. doi: 10.3390/jcm12227000.

Abstract

BACKGROUND

Treating an abdominal aortoiliac aneurysm (AAIA) with endovascular methods can be challenging when the internal iliac artery (IIA) is involved. Embolizing the IIA and extending the limb to the external iliac artery (IIAE + EE) to prevent a type 2 endoleak may lead to pelvic ischemic complications. To avoid these complications, strategies that preserve the IIA, such as the bell-bottom technique (BBT) and the iliac branch device (IBD), have been proposed. This study aims to compare the outcomes of these three endovascular approaches for AAIA.

METHODS

Between January 2010 and December 2019, 174 patients with asymptomatic AAIA were enrolled in this retrospective analysis. They were divided into two groups: 81 patients underwent non-IIAE procedures, and 93 patients underwent IIAE procedures. The iliac limb study group consisted of 106 limbs treated with the BBT, 113 limbs treated with the IIAE + EE, and 32 limbs treated with the IBD. The primary outcomes included the 30-day mortality rate and intraoperative limb complications. The secondary outcomes included postoperative pelvic ischemia, freedom from reintervention, and the overall 10-year survival rate.

RESULTS

There was no significant difference in the perioperative mortality rate between the non-IIAE group (0%) and the IIAE group (2.1%), = 0.500. The intraoperative limb complications did not differ significantly between the BBT limbs (7.5%), the IIAE + EE limbs (3.5%), and the IBD limbs (3.1%) groups, = 0.349. The incidence of buttock claudication was significantly greater in the bilateral IIAE + EE group compared to the unilateral IIAE + EE and non-IIAE groups (25%, 11%, and 2.5%, -value < 0.004), and was similar to the incidence of buttock rest pain with skin necrosis (15%, 0%, and 0%, < 0.001). During the 10-year follow-up, the BBT limbs group had a significantly lower rate of iliac limb reintervention free time than the IIAE + EE limbs and the IBD limbs groups (88.7%, 98.2%, and 93.8%, = 0.016). There was no significant difference in the overall 10-year survival rate between the non-IIAE and IIAE groups (51.4% vs. 55.9%, = 0.703).

CONCLUSIONS

The early and late mortality rates were similar between the non-IIAE and IIAE groups. Preserving the IIA is recommended to avoid pelvic ischemic complications. Considering the higher rate of reintervention in the BBT group, the IBD strategy may be preferred for AAIA.

摘要

背景

当腹主动脉髂动脉瘤(AAIA)累及髂内动脉(IIA)时,采用血管内方法治疗具有挑战性。栓塞IIA并将肢体延伸至髂外动脉(IIAE + EE)以预防2型内漏可能会导致盆腔缺血性并发症。为避免这些并发症,已提出保留IIA的策略,如钟形技术(BBT)和髂分支装置(IBD)。本研究旨在比较这三种血管内治疗AAIA方法的疗效。

方法

在2010年1月至2019年12月期间,174例无症状AAIA患者纳入本回顾性分析。他们被分为两组:81例患者接受非IIAE手术,93例患者接受IIAE手术。髂肢体研究组包括106条接受BBT治疗的肢体、113条接受IIAE + EE治疗的肢体和32条接受IBD治疗的肢体。主要结局包括30天死亡率和术中肢体并发症。次要结局包括术后盆腔缺血、无需再次干预以及总体10年生存率。

结果

非IIAE组(0%)和IIAE组(2.1%)的围手术期死亡率无显著差异,P = 0.500。BBT肢体组(7.5%)、IIAE + EE肢体组(3.5%)和IBD肢体组(3.1%)的术中肢体并发症无显著差异,P = 0.349。双侧IIAE + EE组的臀部间歇性跛行发生率显著高于单侧IIAE + EE组和非IIAE组(25%、11%和2.5%,P值<0.004),且与伴有皮肤坏死的臀部静息痛发生率相似(15%、0%和0%,P < 0.001)。在10年随访期间,BBT肢体组的髂肢体无再次干预时间率显著低于IIAE + EE肢体组和IBD肢体组(88.7%、98.2%和93.8%,P = 0.016)。非IIAE组和IIAE组的总体10年生存率无显著差异(51.4%对55.9%,P = 0.703)。

结论

非IIAE组和IIAE组的早期和晚期死亡率相似。建议保留IIA以避免盆腔缺血性并发症。考虑到BBT组的再次干预率较高,IBD策略可能更适合AAIA。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ead/10672210/3596b80c9c93/jcm-12-07000-g001.jpg

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