State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
School of Life Sciences, Yunnan University, Kunming 650091, China.
Int J Mol Sci. 2023 Nov 11;24(22):16196. doi: 10.3390/ijms242216196.
Six new C-20 and one new C-19 quassinoids, named perforalactones F-L (-), were isolated from twigs of . Spectroscopic and X-ray crystallographic experiments were conducted to identify their structures. Through oxidative degradation of perforalactone B to perforaqussin A, the biogenetic process from C-25 quassinoid to C-20 via Baeyer-Villiger oxidation was proposed. Furthermore, the study evaluated the anti-Parkinson's disease potential of these C-20 quassinoids for the first time on 6-OHDA-induced PC12 cells and a Parkinson's disease model of . Perforalactones G and I ( and ) showed a 10-15% increase in cell viability of the model cells at 50 μM, while compounds and (100 μM) significantly improved the climbing ability of flies and increased the dopamine level in the brains and ATP content in the thoraces of the flies.
从. 的嫩枝中分离得到了 6 个新的 C-20 和 1 个新的 C-19 苦木苦味素，命名为 perforalactones F-L(-)。通过光谱和 X 射线晶体学实验确定了它们的结构。通过将 perforalactone B 氧化降解为 perforaqussin A，提出了 C-25 苦木苦味素通过 Baeyer-Villiger 氧化转化为 C-20 的生物合成过程。此外，该研究首次在 6-OHDA 诱导的 PC12 细胞和. 的帕金森病模型上评估了这些 C-20 苦木苦味素的抗帕金森病潜力。Perforalactones G 和 I（和）在 50 μM 时使模型细胞的细胞活力增加了 10-15%，而化合物（100 μM）显著提高了苍蝇的攀爬能力，并增加了苍蝇大脑中的多巴胺水平和胸部中的 ATP 含量。
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