State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
School of Chemical Science and Engineering, Yunnan University, Kunming 650091, P. R. China.
Org Lett. 2021 Jan 15;23(2):262-267. doi: 10.1021/acs.orglett.0c03460. Epub 2020 Dec 7.
Harpertrioate A (), an A,B,D--limonoid with a rearranged ring B incorporating exocyclic C-30, was isolated from the EtOAc extract of twigs. Its structure, including absolute configurations, was determined on the basis of spectroscopic data and X-ray crystallography. This compound exhibited biological activities against Alzheimer's disease by reducing Aβ42 and Aβ40 production and shifting APP processing toward nonamyloidogenic pathway. The effect of on the Aβ production was comparable to that of gemfibrozil.
Harpertrioate A ()，一种 A，B，D-柠檬苦素，其 B 环经重排后包含 30 位的环外 C 原子，从 的 EtOAc 提取物中分离得到。其结构，包括绝对构型，是基于光谱数据和 X 射线晶体学确定的。该化合物通过减少 Aβ42 和 Aβ40 的产生并使 APP 加工转向非淀粉样途径，表现出抗阿尔茨海默病的生物活性。对 Aβ 产生的影响与 gemfibrozil 相当。
