Department of Social and Medical Sciences, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-077 Bydgoszcz, Poland.
Department of Dermatology and Venerology, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 85-088 Bydgoszcz, Poland.
Int J Mol Sci. 2023 Nov 14;24(22):16295. doi: 10.3390/ijms242216295.
Psoriasis is an inflammatory skin disease that affects 1-2% of the general population. The pathomechanism is based on type 1 immunological reactions. Hyperplasia of the epidermis in psoriasis is a result of disrupted epidermal architecture due to increased synthesis and expression of extracellular matrix proteins. In our study, we analyzed the involvement of periostin (POSTN) in the pathogenesis of psoriasis, as one of the extracellular matrix proteins belonging to the fasciclin family. The study group consisted of 70 patients with psoriasis, while the control group comprised 30 healthy individuals. The serum concentrations of POSTN, Il-6, Il-17, Il-22, TNF-α and IFN-γ were measured in all participants. The severity of psoriasis was determined using the PASI (Psoriasis Area and Severity Index) score. The presence of POSTN in biopsy samples of 50 patients was assessed using the direct immunofluorescence method. The results were subjected to statistical analysis. The serum concentrations of POSTN, Il-6, Il-17, Il-22, TNF-α and IFN-γ in the study group are significantly higher than in the control group. Positive correlation has been demonstrated between the PASI score and the investigated cytokines, but not with POSTN. There was no statistically significant correlation between the POSTN level and the cytokines levels. POSTN deposits were localized in the epidermis in 66% of patients with psoriasis. The role of POSTN in the pathogenesis of psoriasis remains unclear. The mechanisms inducing the synthesis and expression of POSTN in psoriatic skin are not yet fully understood. Further research is needed to enhance our understanding of the mechanism underlying epidermal hyperplasia in psoriasis.
银屑病是一种影响 1-2%普通人群的炎症性皮肤病。其发病机制基于 1 型免疫反应。银屑病表皮增生是由于细胞外基质蛋白合成和表达增加导致表皮结构破坏的结果。在我们的研究中，我们分析了外骨蛋白（POSTN）作为细胞外基质蛋白家族之一在银屑病发病机制中的作用。研究组包括 70 名银屑病患者，对照组包括 30 名健康个体。所有参与者均测量了 POSTN、Il-6、Il-17、Il-22、TNF-α 和 IFN-γ 的血清浓度。使用 PASI（银屑病面积和严重程度指数）评分确定银屑病的严重程度。使用直接免疫荧光法评估 50 名患者活检样本中 POSTN 的存在。对结果进行了统计分析。研究组的 POSTN、Il-6、Il-17、Il-22、TNF-α 和 IFN-γ 的血清浓度明显高于对照组。已经证明 PASI 评分与所研究的细胞因子之间存在正相关，但与 POSTN 无关。POSTN 水平与细胞因子水平之间无统计学显著相关性。66%的银屑病患者表皮中有 POSTN 沉积。POSTN 在银屑病发病机制中的作用尚不清楚。诱导银屑病皮肤中 POSTN 合成和表达的机制尚未完全阐明。需要进一步研究以增强我们对银屑病表皮增生机制的理解。
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