Kasprowicz-Furmańczyk Marta, Narbutt Joanna, Borzęcki Adam, Owczarczyk-Saczonek Agnieszka
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, Olsztyn, Poland.
Department of Dermatology, Paediatric Dermatology and Oncology Clinic, Medical University of Lodz, Lodz, Poland.
Postepy Dermatol Alergol. 2023 Aug;40(4):473-480. doi: 10.5114/ada.2023.129322. Epub 2023 Jul 6.
Plaque psoriasis is a chronic inflammatory dermatosis characterized by a tendency to recur in the same locations after discontinuation of treatment. The implementation of therapy with drugs targeting cytokines like interleukin (IL) 17A (IL-17A) and IL-23 has revolutionized the treatment of psoriasis and enabled the achievement of skin without lesions. However, despite the clinical resolution of psoriatic eruptions, cells that maintain the local memory of the disease remain in the dermis and epidermis, constituting a kind of molecular scar. The cells responsible for maintaining memory in the skin of patients and influencing the rapid relapse of the disease after the triggering factor are primarily tissue resident memory T cells (TRM), but it seems that regulatory T lymphocytes (Treg), dendritic cells (DC), and Langerhans cells (LC) may also play an important role in this process. We reviewed the literature to explain the concept of molecular scarring in psoriasis, and to assess the effect of various therapies on immune memory.
斑块状银屑病是一种慢性炎症性皮肤病，其特征是在治疗中断后倾向于在相同部位复发。使用针对细胞因子如白细胞介素（IL）-17A和IL-23的药物进行治疗，彻底改变了银屑病的治疗方式，并能够实现皮损消退。然而，尽管银屑病皮疹在临床上得到缓解，但维持疾病局部记忆的细胞仍留在真皮和表皮中，构成一种分子瘢痕。在患者皮肤中负责维持记忆并影响触发因素后疾病快速复发的细胞主要是组织驻留记忆T细胞（TRM），但调节性T淋巴细胞（Treg）、树突状细胞（DC）和朗格汉斯细胞（LC）似乎也可能在这一过程中发挥重要作用。我们回顾了文献，以解释银屑病中分子瘢痕形成的概念，并评估各种疗法对免疫记忆的影响。
