The Modulated Role of on Eosinophils in Psychiatric Disorders after Cannabis Cessation.

The aim of our study was to evaluate the impact of status on eosinophils count (EOS), the eosinophil-to-lymphocyte ratio (ELR), and the eosinophil-to-neutrophil-to-lymphocytes ratio (ENLR) before and after cannabis cessation in patients with psychiatric disorders. One hundred and eighty-eight patients were included in the study. , EOS, ELR, ENLR, and urinary cannabis were measured at baseline and after 4 weeks of cannabis cessation. Highest levels and increase of PNE ( = 0.02), ENLR levels ( = 0.031) and highest level of ELR ( = 0.03) were found in patients after cannabis cessation only in patients positive for serology (Toxo+ group). At four weeks, significant interactions between cannabis and status for EOS ( = 0.038), and for ENLR ( = 0.043) levels were found, as well as for the evolution between baseline and 4 weeks for ENLR level ( = 0.049). After cannabis cessation, we found a positive correlation between negative symptoms and EOS levels at 4 weeks in the Toxo+ group. This study shows that the increase of inflammation after cannabis cessation might be modulated by seropositivity status in patients after cannabis cessation.