外周血嗜酸性粒细胞计数和嗜酸性粒细胞与淋巴细胞比值（ELR）对 COVID-19 患者临床病程的影响：一项回顾性研究。
The Impact of Peripheral Eosinophil Counts and Eosinophil to Lymphocyte Ratio (ELR) in the Clinical Course of COVID-19 Patients: A Retrospective Study.
机构信息
Department of Pulmonology, Laiko General Hospital, Athens, Greece.
First Department of Pulmonology, Sismanogleio Hospital, Athens, Greece.
出版信息
In Vivo. 2021 Jan-Feb;35(1):641-648. doi: 10.21873/invivo.12303.
BACKGROUND/AIM: Eosinophils are blood cells responsible for response against parasites and allergens. Eosinophil to lymphocyte ratio (ELR) is a biomarker for inflammatory conditions. Our aim was to evaluate the role of eosinophils and ELR in COVID-19 patients.
PATIENTS AND METHODS
The study included 96 patients hospitalized with COVID-19. They were classified into moderate to severe cases and critical cases. Eosinophils and ELR were determined in both groups, in patients that died or survived and were correlated to duration of hospitalization.
RESULTS
There was a statistically significant decrease in eosinophils and ELR between patients that died and patients that survived (p<0.05), and in mean values of the two biomarkers (p<0.05 for eosinophils and p<0.05 for ELR) between patients hospitalized for more or less than 15 days among those with moderate to severe disease.
CONCLUSION
Lower eosinophil counts and ERL could probably predict worse outcome in COVID-19 patients.
背景/目的：嗜酸性粒细胞是对抗寄生虫和过敏原的血细胞。嗜酸性粒细胞与淋巴细胞比值（ELR）是炎症状态的生物标志物。我们的目的是评估嗜酸性粒细胞和 ELR 在 COVID-19 患者中的作用。
患者和方法
该研究纳入了 96 名因 COVID-19 住院的患者。他们被分为中度至重度病例和危急病例。在两组患者中均测定了嗜酸性粒细胞和 ELR，比较了死亡患者和存活患者之间以及在中度至重度疾病中住院时间超过或少于 15 天的患者之间这两个生物标志物的均值。
结果
死亡患者的嗜酸性粒细胞和 ELR 明显低于存活患者（p<0.05），在中度至重度疾病中住院时间超过或少于 15 天的患者中，这两个生物标志物的均值也明显降低（嗜酸性粒细胞 p<0.05，ELR p<0.05）。
结论
嗜酸性粒细胞计数和 ELR 降低可能预示 COVID-19 患者预后不良。
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