Chaulin Aleksey Michailovich
Department of Histology and Embryology, Samara State Medical University, Samara 443099, Russia.
Department of Clinical Chemistry, Samara State Medical University, Samara 443099, Russia.
Life (Basel). 2023 Oct 31;13(11):2148. doi: 10.3390/life13112148.
The study of mechanisms underlying cardiotoxicity of doxorubicin and the development of strategies to mitigate doxorubicin-induced cardiotoxicity are the most relevant issues of modern cardio-oncology. This is due to the high prevalence of cancer in the population and the need for frequent use of highly effective chemotherapeutic agents, in particular anthracyclines, for optimal management of cancer patients. However, while being a potent agent to counteract cancer, doxorubicin also affects the cardiovascular systems of patients undergoing chemotherapy in a significant and unfavorable fashion. Consecutively reviewed in this article are risk factors and mechanisms of doxorubicin cardiotoxicity, and the essential strategies to mitigate cardiotoxic effects of doxorubicin treatment in cancer patients are discussed.
多柔比星心脏毒性的潜在机制研究以及减轻多柔比星诱导的心脏毒性策略的开发是现代心脏肿瘤学中最相关的问题。这是由于人群中癌症的高发病率以及为了对癌症患者进行最佳管理而频繁使用高效化疗药物，特别是蒽环类药物的需求。然而，尽管多柔比星是对抗癌症的有效药物，但它也以显著且不利的方式影响接受化疗患者的心血管系统。本文依次综述了多柔比星心脏毒性的危险因素和机制，并讨论了减轻癌症患者多柔比星治疗心脏毒性作用的重要策略。
