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(Schw.) Wolf，一种传统的中国食用药用草本植物，可促进神经干细胞/祖细胞中神经元的分化和新生神经元的形态成熟。

(Schw.) Wolf, a Traditional Chinese Edible Medicinal Herb, Promotes Neuronal Differentiation, and the Morphological Maturation of Newborn Neurons in Neural Stem/Progenitor Cells.

机构信息

Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province, College of Biological and Food Engineering, Huaihua University, Huaihua 418008, China.

College of Chemistry and Materials Engineering, Huaihua University, Huaihua 418008, China.

出版信息

Molecules. 2023 Nov 8;28(22):7480. doi: 10.3390/molecules28227480.

DOI:10.3390/molecules28227480
PMID:38005201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10672746/
Abstract

Neurogenesis in the adult brain comprises the entire set of events of neuronal development. It begins with the division of precursor cells to form a mature, integrated, and functioning neuronal network. Adult neurogenesis is believed to play an important role in animals' cognitive abilities, including learning and memory. In the present study, significant neuronal differentiation-promoting activity of 80% (/) ethanol extract of (EEPC) was found in Neuro-2a cells and mouse cortical neural stem/progenitor cells (NSPCs). Subsequently, a total of 97 compounds in EEPC were identified by UHPLC-Q-Exactive-MS/MS. Among them, four major compounds-Adenosine; Choline; Ethyl palmitoleate; and L-(-)-arabinitol-were further studied for their neuronal differentiation-promoting activity. Of which, choline has the most significant neuronal differentiation-promoting activity, indicating that choline, as the main bioactive compound in , may have a positive effect on learning and memory functions. Compared with similar research literature, this is the first time that the neuronal differentiation-promoting effects of extract have been studied.

摘要

成人脑内的神经发生包括了神经元发育的所有事件。它始于前体细胞的分裂，形成一个成熟、整合和功能齐全的神经元网络。成人神经发生被认为在动物的认知能力中起着重要作用，包括学习和记忆。在本研究中，从 （EEPC）中分离得到的 80%（/）乙醇提取物在Neuro-2a 细胞和小鼠皮质神经干细胞/祖细胞（NSPCs）中表现出显著的神经元分化促进活性。随后，通过 UHPLC-Q-Exactive-MS/MS 共鉴定出 EEPC 中的 97 种化合物。其中，阿腺苷、胆碱、棕榈油酸乙酯和 L-(-)-阿拉伯糖醇等 4 种主要化合物被进一步研究其神经元分化促进活性。其中，胆碱的神经元分化促进活性最为显著，表明作为 的主要生物活性化合物，胆碱可能对学习和记忆功能有积极影响。与类似的研究文献相比，这是首次研究 提取物的神经元分化促进作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/c52b470c7cc0/molecules-28-07480-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/4ddef0a8dfb1/molecules-28-07480-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/5e3ac6a87bbc/molecules-28-07480-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/91cd59da5f78/molecules-28-07480-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/2ef72abdc118/molecules-28-07480-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/04244a8fd080/molecules-28-07480-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/c52b470c7cc0/molecules-28-07480-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/4ddef0a8dfb1/molecules-28-07480-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/5e3ac6a87bbc/molecules-28-07480-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/91cd59da5f78/molecules-28-07480-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/2ef72abdc118/molecules-28-07480-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/04244a8fd080/molecules-28-07480-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6fb/10672746/c52b470c7cc0/molecules-28-07480-g006.jpg

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