Isenberg S J, McRee W E, Jedrzynski M S, Gange S N, Gange S L
Arch Intern Med. 1987 Jan;147(1):67-9.
Because conjunctival vessels are affected by sickle cell disease, we wanted to see if conjunctival PO2 (partial oxygen tension) and temperature were also affected and if these measurements could aid in managing these patients. Conjunctival PO2 and temperature in 23 asymptomatic homozygous patients with sickle cell anemia did not differ significantly from those in age-matched controls. However, 12 subjects in painful sickle cell crisis had a significantly lower conjunctival PO2 than before crisis despite no significant change in hematocrit and conjunctival temperature. Supplemental oxygen therapy significantly increased conjunctival PO2. When supplemental oxygen was removed, conjunctival PO2 decreased to the admission level despite clinical improvement. This finding supports the use of supplemental oxygen in treating crisis. Measuring conjunctival PO2 can give clinicians an assessment of the effect of sickle cell disease on a peripheral capillary bed and may provide the first objective method to reliably diagnose acute painful sickle cell crisis.
由于镰状细胞病会影响结膜血管，我们想了解结膜的氧分压（PO2）和温度是否也会受到影响，以及这些测量指标能否有助于对这些患者进行管理。23例无症状的镰状细胞贫血纯合子患者的结膜PO2和温度与年龄匹配的对照组相比，差异无统计学意义。然而，12例处于镰状细胞疼痛危象的受试者，尽管血细胞比容和结膜温度无显著变化，但结膜PO2明显低于危象前。补充氧气疗法可显著提高结膜PO2。当停止补充氧气时，尽管临床症状有所改善，但结膜PO2降至入院时水平。这一发现支持在治疗危象时使用补充氧气。测量结膜PO2可以让临床医生评估镰状细胞病对周围毛细血管床的影响，并可能提供首个可靠诊断急性镰状细胞疼痛危象的客观方法。
