腰椎神经根病与骨折风险：一项韩国全国基于人群的队列研究。

Lumbar radiculopathy and fracture risk: A Korean nationwide population-based cohort study.

机构信息

Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Bucheon 14584, Republic of Korea.

Department of Orthopaedic Surgery, Ajou University School of Medicine, Suwon 16499, Republic of Korea.

出版信息

Bone. 2024 Feb;179:116981. doi: 10.1016/j.bone.2023.116981. Epub 2023 Nov 24.

DOI:10.1016/j.bone.2023.116981

PMID:38008302

Abstract

INTRODUCTION

Lumbar radiculopathy is a common disease with a high economic burden, and fractures in adults are a significant public health problem. However, studies of the relationship between lumbar radiculopathy and fractures are scarce. We investigated the fracture risk in patients with lumbar radiculopathy.

METHODS

This nationwide retrospective cohort study identified 815,101 patients with lumbar radiculopathy and randomly matched individuals without lumbar radiculopathy (1:1) who were included in the Korean National Health Insurance System in 2012. Cox proportional hazards regression analyses were performed to calculate the hazard ratio (HR) for fracture risk in patients with lumbar radiculopathy.

RESULTS

The study included 301,347 patients with lumbar radiculopathy and matched 289,618 individuals without lumbar radiculopathy. Compared to individuals without lumbar radiculopathy, patients with lumbar radiculopathy had a 27 % increased fracture risk (adjusted HR = 1.27, 95 % confidence interval = 1.24-1.31). The Kaplan-Meier plot showed a significantly higher fracture incidence in patients with lumbar radiculopathy than in individuals without lumbar radiculopathy at all times.

CONCLUSION

Lumbar radiculopathy is significantly associated with fracture risk.

摘要

简介

腰椎神经根病是一种常见疾病，经济负担重，成年人骨折是一个重大的公共卫生问题。然而，腰椎神经根病与骨折之间关系的研究却很少。我们研究了腰椎神经根病患者的骨折风险。

方法

这是一项全国性的回顾性队列研究，共纳入了 815101 名患有腰椎神经根病的患者，并随机匹配了 2012 年韩国国家健康保险系统中没有腰椎神经根病的患者（1:1）。使用 Cox 比例风险回归分析计算腰椎神经根病患者骨折风险的风险比（HR）。

结果

该研究纳入了 301347 名患有腰椎神经根病的患者，并匹配了 289618 名没有腰椎神经根病的患者。与没有腰椎神经根病的患者相比，患有腰椎神经根病的患者骨折风险增加了 27%（调整后的 HR=1.27，95%置信区间=1.24-1.31）。Kaplan-Meier 图显示，在所有时间点，患有腰椎神经根病的患者骨折发生率明显高于没有腰椎神经根病的患者。