Houben P W, Bullock L P, Fox T O
Biochem Genet. 1986 Dec;24(11-12):805-11. doi: 10.1007/BF00554520.
Renal weight and beta-glucuronidase activity are two of several well-characterized androgen-responsive parameters in Mus musculus. A similar sexual dimorphism was not reported for a second mouse species, Mus caroli, however. Since this was not associated with a general absence of androgen action, we considered whether a localized defect in androgen receptors or a difference in renal androgen-responsive endpoints in the two species existed. Only minor differences in the characteristics of renal androgen receptors from the two species were found when they were analyzed by two different methods. These differences were not thought to be sufficient to account for the apparent renal androgen unresponsiveness. No differences were found in androgen receptors from brain. Subsequently, a third renal endpoint, ornithine decarboxylase activity, was found to respond to androgen stimulation in Mus caroli. Control of renal androgen action in these two mouse species thus differs at the level of genetic regulatory elements.
肾重量和β-葡萄糖醛酸酶活性是小家鼠中几个特征明确的雄激素反应参数中的两个。然而，对于另一种小鼠物种——卡罗小鼠，并未报道类似的性别二态性。由于这与雄激素作用的普遍缺失无关，我们考虑这两个物种是否存在雄激素受体的局部缺陷或肾雄激素反应终点的差异。当通过两种不同方法分析时，发现这两个物种的肾雄激素受体特征仅有微小差异。这些差异被认为不足以解释明显的肾雄激素无反应性。在脑的雄激素受体中未发现差异。随后，发现第三个肾终点——鸟氨酸脱羧酶活性在卡罗小鼠中对雄激素刺激有反应。因此，这两种小鼠物种中肾雄激素作用的调控在基因调控元件水平上存在差异。
