Takallou Ahmad, Al-Siyabi Munir, Al-Shidhani Sulaiman, Lotfi Nosood Yazdanbakhsh, Habibi Azizollah, Almaani Alhajaj, Anwar Muhammad U, Al-Harrasi Ahmed
Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman.
Faculty of Chemistry, Kharazmi University, Daneshgah Square, Shahid Beheshti Street, 31979-37551, Karaj, Iran.
Org Biomol Chem. 2023 Dec 13;21(48):9530-9533. doi: 10.1039/d3ob01768k.
A Pd-catalyzed selective tandem cyclization of the Ugi adduct Buchwald-Hartwig/C-H bond functionalization reactions has been reported. This sequence offers an interesting approach for synthesizing a wide range of pyrido[1,2-]pyrazine-3,6-dione scaffolds under mild reaction conditions in moderate to excellent yields. The scope and limitations of the protocol are discussed.
已报道了钯催化的Ugi加合物的选择性串联环化反应——布赫瓦尔德-哈特维希/C-H键官能团化反应。该反应序列为在温和反应条件下以中等至优异产率合成多种吡啶并[1,2 - ]吡嗪-3,6-二酮骨架提供了一种有趣的方法。本文还讨论了该方法的适用范围和局限性。
