三种碳青霉烯类药物在单日内剂量对耐碳青霉烯肠定植耐药性的影响。
The impact of three carbapenems at a single-day dose on intestinal colonization resistance against carbapenem-resistant .
机构信息
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
出版信息
mSphere. 2023 Dec 20;8(6):e0047923. doi: 10.1128/msphere.00479-23. Epub 2023 Nov 27.
Abstract
The intestinal colonization of carbapenem-resistant (CRKP) is an important source of clinical infection. Our research showed that even single-day dose use of carbapenems caused CRKP colonization and continuous bacterial shedding, which reminds clinical doctors to prescribe carbapenems cautiously. Whenever possible, ertapenem should be the preferred choice over other carbapenems especially when the identified or highly suspected pathogens can be effectively targeted by ertapenem.
摘要
耐碳青霉烯肠杆菌科（CRKP）定植是临床感染的重要来源。我们的研究表明，即使是单次使用碳青霉烯类药物也会导致 CRKP 定植和持续细菌脱落，这提醒临床医生谨慎使用碳青霉烯类药物。只要有可能，厄他培南应优先选择其他碳青霉烯类药物，特别是当鉴定或高度怀疑的病原体可以被厄他培南有效靶向时。
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