Baig Mirza Muhammad Faran Ashraf, Wong Lok Yin, Wu Hongkai
Department of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration, The Hong Kong University of Science and Technology, Hong Kong, China.
J Drug Target. 2024 Dec;32(1):21-32. doi: 10.1080/1061186X.2023.2288996. Epub 2024 Jan 12.
This review has focused on the development of mRNA nano-vaccine and the biochemical interactions of anti-COVID-19 mRNA vaccines with various disease conditions and age groups. It studied five major groups of individuals with different disease conditions and ages, including allergic background, infarction background, adolescent, and adult (youngsters), pregnant women, and elderly. All five groups had been reported to have background-related adverse effects. Allergic background individuals were observed to have higher chances of experiencing allergic reactions and even anaphylaxis. Individuals with an infarction background had a higher risk of vaccine-induced diseases, e.g. pneumonitis and interstitial lung diseases. Pregnant women were seen to suffer from obstetric and gynecological adverse effects after receiving vaccinations. However, interestingly, the elderly individuals (> 65 years old) had experienced milder and less frequent adverse effects compared to the adolescent (<19 and >9 years old) and young adulthood (19-39 years old), or middle adulthood (40-59 years old) age groups, while middle to late adolescent (14-17 years old) was the riskiest age group to vaccine-induced cardiovascular manifestations.
本综述聚焦于mRNA纳米疫苗的发展以及抗新冠病毒mRNA疫苗与各种疾病状况和年龄组的生化相互作用。它研究了五组患有不同疾病状况和年龄的个体，包括有过敏背景、梗死背景的个体、青少年、成年人（年轻人）、孕妇和老年人。据报道，所有这五组人群都有与背景相关的不良反应。有过敏背景的个体出现过敏反应甚至过敏症的几率更高。有梗死背景的个体患疫苗诱导疾病的风险更高，如肺炎和间质性肺病。孕妇在接种疫苗后会出现妇产科方面的不良反应。然而，有趣的是，与青少年（<19岁且>9岁）、青年期（19 - 39岁）或中年期（40 - 59岁）年龄组相比，老年人（>65岁）经历的不良反应更轻微且频率更低，而青少年中后期（14 - 17岁）是疫苗诱导心血管表现的风险最高年龄组。
