Semenova N V, Vyrupaeva E V, Kolesnikov S I, Sholokhov L F, Rychkova L V, Petrova A G, Akhmedzyanova M R, Darenskaya M A, Kolesnikova L I
Scientific Сentre for Family Health and Human Reproduction Problems, 16 Timiryazev str., Irkutsk 664003, Russian Federation, e-mail:
Adv Gerontol. 2023;36(4):477-483.
Climacteric women have the post-COVID period clinical features, which can lead to an acceleration of the aging. The study consists in assessing individual parameters of the neuroendocrine system in climacteric women with a moderate course of COVID-19 and 12 months after the disease. Under observation were women aged 45-69 years, who were divided into groups: women who did not have COVID-19, not vaccinated, with no antibodies to COVID-19 (IgG) - control group (n=16); women in the acute phase of COVID-19 with a moderate course, accompanied by pneumonia - main group (n=63); patients from the main group who agreed to be examined 12 months after COVID-19 (n=15). The prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, cortisol, testosterone, 17-OH-progesterone, dihydroepiandrosterone sulfate (DHEA-S) levels were assessed. In women with COVID-19 compared with the control the prolactin level was increased (p=0,0002) and the estradiol (р=0,032), testosterone (p=0,004), cortisol (p=0,009), 17-OH-progesterone (p=0,025) and DHEA-S (p=0,003) levels were reduced. Intragroup comparison of hormones showed a decrease in the prolactin level (р=0,041) and increase in the 17-OH-progesterone (р=0,011) and DHEA-S (р=0,0006) levels 12 months after the disease. With a personalized consideration of this group a decrease in the prolactin level is observed in 73,3% of these patients. In the same period, there was an increase in testosterone levels in 46,7% of women, cortisol - in 73,3% of women, 17-OH-progesterone - in 80% of women, DHEA-S - in 100% of cases. When comparing these hormonal parameters between the group of patients who recovered from COVID-19 12 months ago and the control, no statistically significant differences were found, however, patients were identified in whom prolactin and cortisol exceeded the reference values, although in the acute phase of COVID-19 the values of these indicators corresponded to the reference values.
更年期女性具有新冠后时期的临床特征，这可能导致衰老加速。该研究旨在评估患有中度新冠病程的更年期女性以及患病12个月后的神经内分泌系统各项参数。接受观察的是45至69岁的女性，她们被分为几组：未感染新冠、未接种疫苗且无新冠抗体（IgG）的女性——对照组（n = 16）；处于新冠中度病程急性期且伴有肺炎的女性——主要组（n = 63）；主要组中同意在新冠后12个月接受检查的患者（n = 15）。评估了催乳素、黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇、皮质醇、睾酮、17-羟孕酮、硫酸脱氢表雄酮（DHEA-S）的水平。与对照组相比，感染新冠的女性催乳素水平升高（p = 0.0002），而雌二醇（p = 0.032）、睾酮（p = 0.004）、皮质醇（p = 0.009）、17-羟孕酮（p = 0.025）和DHEA-S（p = 0.003）水平降低。激素的组内比较显示，患病12个月后催乳素水平降低（p = 0.041），17-羟孕酮（p = 0.011）和DHEA-S（p = 0.0006）水平升高。对该组进行个体化考量时，73.3%的这些患者出现催乳素水平降低。同期，46.7%的女性睾酮水平升高，73.3%的女性皮质醇水平升高，80%的女性17-羟孕酮水平升高，100%的病例DHEA-S水平升高。在比较12个月前从新冠中康复的患者组与对照组之间的这些激素参数时，未发现统计学上的显著差异，然而，发现有患者的催乳素和皮质醇超过参考值，尽管在新冠急性期这些指标的值与参考值相符。
