Zelewski M, Swierczyński J
Biochem Int. 1986 Oct;13(4):591-8.
Clofibrate administration by stomach tube or intraperitoneally for 3 successive days to rats fed standard diet or starved for 72 hr caused about 2-fold increase of malic enzyme activity in the liver and adipose tissue. The drug administered by stomach tube (but not intraperitoneally) to the rats fed fat free-high carbohydrate diet significantly blocked the inducing effect of the diet on malic enzyme activity in both tissues. Clofibrate blocked the induction by fat free-high carbohydrate diet of hexose monophosphate shunt dehydrogenases and ATP-citrate lyase in the liver. The amount of fat free-high carbohydrate diet consumed by rats received clofibrate by stomach tube was much less than by untreated animals. It is concluded therefore that the significant decrease of food consumption by rats receiving clofibrate by stomach tube is responsible for the inhibitory effect of the drug on some lipogenic enzymes activity induced by fat free-high carbohydrate diet.
通过胃管或腹腔注射连续3天将氯贝丁酯给予喂食标准饮食或饥饿72小时的大鼠，导致肝脏和脂肪组织中苹果酸酶活性增加约2倍。通过胃管（而非腹腔注射）将该药物给予喂食无脂肪高碳水化合物饮食的大鼠，显著阻断了该饮食对两种组织中苹果酸酶活性的诱导作用。氯贝丁酯阻断了无脂肪高碳水化合物饮食对肝脏中磷酸己糖旁路脱氢酶和ATP - 柠檬酸裂解酶的诱导作用。通过胃管接受氯贝丁酯的大鼠所消耗的无脂肪高碳水化合物饮食量远少于未处理的动物。因此得出结论，通过胃管接受氯贝丁酯的大鼠食物摄入量显著减少，是该药物对无脂肪高碳水化合物饮食诱导的某些脂肪生成酶活性产生抑制作用的原因。
