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白细胞介素-6 与早产的关系：一项荟萃分析。

Association between interleukin-6 and preterm birth: a meta-analysis.

机构信息

Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin Central Hospital of Obstetrics Gynecology, Tianjin, China.

Nankai University, Tianjin, China.

出版信息

Ann Med. 2023;55(2):2284384. doi: 10.1080/07853890.2023.2284384. Epub 2023 Nov 27.

DOI:10.1080/07853890.2023.2284384
PMID:38010798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10836263/
Abstract

BACKGROUND

Interleukin (IL)-6 is a pro-inflammatory cytokine that plays an important role in preterm birth (PTB), Several meta-analyses investigated the association between IL-6 and PTB, but definitive conclusion has not yet been achieved. This updated meta-analysis aimed to ascertain the association between IL-6 and PTB by examining IL-6 levels in both normal birth and PTB groups.

MATERIAL AND METHODS

Prospective cohort studies were retrieved in PubMed, Embase, and the Cochrane library from their inception until 18 February 2020. The primary outcome was the association between IL-6 and PTB, and secondary outcomes were the association between IL-6 and spontaneous PTB.

RESULTS

Nine studies involving 1904 patients were included. Overall, IL-6 from different sample types (maternal blood, amniotic fluid and cervicovaginal fluid) was associated with PTB (standard mean difference [SMD]: 0.86, 95% confidence interval [CI]: 0.32 to 1.39,  < 0.001). Furthermore, the association was significant for IL-6 only in amniotic fluid (SMD: 1.87, 95%CI: 0.82 to 2.93,  < 0.001) and cervicovaginal fluid (SMD: 0.46, 95%CI: 0.09 to 0.84,  = 0.022), but not significant in maternal blood (SMD: -0.11, 95%CI: -0.57 to 0.34,  = 0.623). In addition, IL-6 was also associated with spontaneous PTB (SMD: 1.57, 95% CI: 0.18 to 2.95,  < 0.001).

CONCLUSIONS

Based on the available evidence, IL-6 in amniotic fluid and cervicovaginal fluid might be useful for predicting preterm birth.

摘要

背景

白细胞介素（IL）-6 是一种促炎细胞因子，在早产（PTB）中发挥重要作用。几项荟萃分析研究了 IL-6 与 PTB 之间的关系，但尚未得出明确的结论。本更新的荟萃分析旨在通过检查正常分娩和 PTB 组中的 IL-6 水平来确定 IL-6 与 PTB 之间的关系。

材料和方法

在 PubMed、Embase 和 Cochrane 图书馆中检索了从成立到 2020 年 2 月 18 日的前瞻性队列研究。主要结局是 IL-6 与 PTB 之间的关系，次要结局是 IL-6 与自发性 PTB 之间的关系。

结果

纳入了 9 项涉及 1904 名患者的研究。总体而言，来自不同样本类型（母体血液、羊水和宫颈阴道分泌物）的 IL-6 与 PTB 相关（标准均数差 [SMD]：0.86，95%置信区间 [CI]：0.32 至 1.39，  < 0.001）。此外，仅在羊水（SMD：1.87，95%CI：0.82 至 2.93，  < 0.001）和宫颈阴道分泌物（SMD：0.46，95%CI：0.09 至 0.84，  = 0.022）中 IL-6 的相关性具有统计学意义，但在母体血液中无统计学意义（SMD：-0.11，95%CI：-0.57 至 0.34，  = 0.623）。此外，IL-6 还与自发性 PTB 相关（SMD：1.57，95%CI：0.18 至 2.95，  < 0.001）。

结论

根据现有证据，羊水和宫颈阴道分泌物中的 IL-6 可能有助于预测早产。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae5b/10836263/8530117a62e2/IANN_A_2284384_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae5b/10836263/13e60937c95a/IANN_A_2284384_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae5b/10836263/bfcd663938c0/IANN_A_2284384_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae5b/10836263/8530117a62e2/IANN_A_2284384_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae5b/10836263/13e60937c95a/IANN_A_2284384_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae5b/10836263/bfcd663938c0/IANN_A_2284384_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae5b/10836263/8530117a62e2/IANN_A_2284384_F0003_C.jpg

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