感染性鹿角形结石的辅助化疗

Adjunctive chemotherapy of infection-induced staghorn calculi.

作者信息

Griffith D P, Moskowitz P A, Carlton C E

出版信息

Trans Am Assoc Genitourin Surg. 1978;70:25-9.

Abstract

Bacteria induce urinary crystallization of struvite and carbonate-apatite as a by-product of ureolysis by urease. Eradication of infection and/or inhibition of urease with acetohydroxamic acid for 5 to 30 months retarded stone growth and brought about partial or complete dissolution of stones in 9 patients. Long-term chemotherapy with antimicrobial agents that achieve sterile urine or acetohydroxamic acid in those patients with recalcitrant infection lessens the risk of recurrent calculogenesis.

摘要

细菌通过尿素酶分解尿素，促使鸟粪石和碳酸磷灰石在尿液中结晶。用乙酰氧肟酸根除感染和/或抑制尿素酶5至30个月，可延缓结石生长，并使9例患者的结石部分或完全溶解。对于那些顽固性感染患者，使用能使尿液无菌的抗菌药物或乙酰氧肟酸进行长期化疗，可降低结石复发的风险。