Chen Yuling, Dong Xin, Wang Yixin, Li Yu, Xiong Lidan, Li Li
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Center of Cosmetics Evaluation, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
J Cosmet Dermatol. 2024 Apr;23(4):1131-1140. doi: 10.1111/jocd.16093. Epub 2023 Nov 27.
Non-scarring alopecia mainly includes androgenetic alopecia (AGA), female pattern hair loss (FPHL), alopecia areata (AA), telogen effluvium (TE), anagen effluvium (AE) and so on. Many studies had investigated the serum 25-hydroxyvitamin D level and vitamin D deficiency of patients with these diseases, but opinions varied, and no conclusion was reached.
Relevant articles were retrieved through PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and other databases. Serum 25-hydroxyvitamin D [25(OH) D] levels and vitamin D deficiency were used as our primary outcome. The odds ratio (OR) and the standardized mean difference (SMD) with 95% confidence interval were both examined for vitamin D deficiency and levels.
Our meta-analysis had included a total of 3374 non-scarring alopecia patients and 7296 healthy controls from 23 studies through the inclusion criteria and exclusion criteria. We found non-scarring alopecia had decreased serum 25(OH)D level (WMD -7.29; 95% CI -9.21, -5.38) and increased vitamin D deficiency incidence (OR 3.11 95% CI 2.29, 4.22), compared with healthy controls. This meta-analysis chose to conduct random-effect model and subgroup analysis, because of the high heterogeneity (serum 25(OH)D level: I 95%, vitamin D deficiency: I = 0%).
Patients with non-scarring alopecia (including AA, FPHL, AGA and TE) have insufficient serum level of 25(OH)D and increased incidence of vitamin D deficiency. Vitamin D supplementation and monitoring for vitamin D deficiency may be helpful in treating non-scarring alopecia.
非瘢痕性脱发主要包括雄激素性脱发（AGA）、女性型脱发（FPHL）、斑秃（AA）、休止期脱发（TE）、生长期脱发（AE）等。许多研究调查了这些疾病患者的血清25-羟基维生素D水平和维生素D缺乏情况，但观点不一，未达成结论。
通过PubMed、Web of Science、EMBASE、Cochrane图书馆、中国知网（CNKI）等数据库检索相关文章。血清25-羟基维生素D[25(OH)D]水平和维生素D缺乏作为主要结局指标。对维生素D缺乏情况和水平进行了比值比（OR）及95%置信区间的标准化均数差（SMD）检验。
通过纳入标准和排除标准，我们的荟萃分析共纳入了来自23项研究的3374例非瘢痕性脱发患者和7296例健康对照。我们发现，与健康对照相比，非瘢痕性脱发患者血清25(OH)D水平降低（加权均数差-7.29；95%置信区间-9.21，-5.38），维生素D缺乏发生率增加（OR 3.11，95%置信区间2.29，4.22）。由于异质性高（血清25(OH)D水平：I² = 95%，维生素D缺乏：I² = 0%），本荟萃分析选择进行随机效应模型和亚组分析。
非瘢痕性脱发（包括斑秃、女性型脱发、雄激素性脱发和休止期脱发）患者血清25(OH)D水平不足，维生素D缺乏发生率增加。补充维生素D并监测维生素D缺乏情况可能有助于治疗非瘢痕性脱发。
