Chen Shuting, Li Ling, Ding Wei, Zhu Yueqian, Zhou Naihui
Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Drug Des Devel Ther. 2025 Aug 25;19:7349-7363. doi: 10.2147/DDDT.S542000. eCollection 2025.
Androgenetic Alopecia (AGA) is a common type of alopecia. The pathogenesis of AGA involves genetic predisposition, androgen metabolism, inflammation, fibrosis, and impaired energy metabolism. The choice of therapeutic agents for the treatment of AGA remains controversial globally, with finasteride and minoxidil being the only two widely recognized and legally approved therapeutic options. In recent years, significant progress has been made in the development of drugs targeting different pathogenic mechanisms of AGA. This article reviews the main drugs currently used for AGA treatment. By summarizing their mechanisms of action and clinical efficacy, it aims to provide a comprehensive theoretical basis and clinical reference for the treatment of AGA.
雄激素性脱发（AGA）是一种常见的脱发类型。AGA的发病机制涉及遗传易感性、雄激素代谢、炎症、纤维化和能量代谢受损。在全球范围内，用于治疗AGA的治疗药物选择仍存在争议，非那雄胺和米诺地尔是仅有的两种得到广泛认可且经法律批准的治疗选择。近年来，针对AGA不同致病机制的药物研发取得了重大进展。本文综述了目前用于治疗AGA的主要药物。通过总结它们的作用机制和临床疗效，旨在为AGA的治疗提供全面的理论依据和临床参考。
