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磁场对 1.5TMR 直线加速器中新型闪烁剂量计的影响。

Influence of magnetic field on a novel scintillation dosimeter in a 1.5 T MR-linac.

机构信息

Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.

Blue Physics, Lutz, Florida, USA.

出版信息

J Appl Clin Med Phys. 2024 Jan;25(1):e14180. doi: 10.1002/acm2.14180. Epub 2023 Nov 27.

DOI:10.1002/acm2.14180
PMID:38011008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10795437/
Abstract

For commissioning and quality assurance for adaptive workflows on the MR-linac, a dosimeter which can measure time-resolved dose during MR image acquisition is desired. The Blue Physics model 10 scintillation dosimeter is potentially an ideal detector for such measurements. However, some detectors can be influenced by the magnetic field of the MR-linac. To assess the calibration methods and magnetic field dependency of the Blue Physics scintillator in the 1.5 T MR-linac. Several calibration methods were assessed for robustness. Detector characteristics and the influence of the calibration methods were assessed based on dose reproducibility, dose linearity, dose rate dependency, relative output factor (ROF), percentage depth dose profile, axial rotation and the radial detector orientation with respect to the magnetic field. The potential application of time-resolved dynamic dose measurements during MRI acquisition was assessed. A variation of calibration factors was observed for different calibration methods. Dose reproducibility, dose linearity and dose rate stability were all found to be within tolerance and were not significantly affected by different calibration methods. Measurements with the detector showed good correspondence with reference chambers. The ROF and radial orientation dependence measurements were influenced by the calibration method used. Axial detector dependence was assessed and relative readout differences of up to 2.5% were observed. A maximum readout difference of 10.8% was obtained when rotating the detector with respect to the magnetic field. Importantly, measurements with and without MR image acquisition were consistent for both static and dynamic situations. The Blue Physics scintillation detector is suitable for relative dosimetry in the 1.5 T MR-linac when measurements are within or close to calibration conditions.

摘要

为了在 MR 直线加速器上对自适应工作流程进行调试和质量保证,需要一种能够在 MR 图像采集期间测量时变剂量的剂量计。Blue Physics 型号 10 闪烁体剂量计可能是此类测量的理想探测器。然而,一些探测器可能会受到 MR 直线加速器磁场的影响。为了评估 Blue Physics 闪烁体在 1.5T MR 直线加速器中的校准方法和磁场依赖性,评估了几种校准方法的稳健性。基于剂量重复性、剂量线性度、剂量率依赖性、相对输出因子(ROF)、百分深度剂量分布、轴向旋转和探测器相对于磁场的径向方向,评估了探测器特性和校准方法的影响。评估了在 MRI 采集期间进行时变动态剂量测量的潜在应用。观察到不同校准方法的校准因子存在变化。剂量重复性、剂量线性度和剂量率稳定性均在允许范围内,且不受不同校准方法的显著影响。探测器的测量结果与参考室具有良好的一致性。ROF 和径向方向依赖性测量受到所用校准方法的影响。评估了轴向探测器依赖性,并观察到高达 2.5%的相对读出差异。当相对于磁场旋转探测器时,最大读出差异为 10.8%。重要的是,对于静态和动态情况,无论是在进行还是未进行 MR 图像采集时,测量结果均一致。Blue Physics 闪烁体探测器适用于 1.5T MR 直线加速器中的相对剂量测量,前提是测量值在或接近校准条件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/18d4949e32c6/ACM2-25-e14180-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/2173dde91e93/ACM2-25-e14180-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/c8be4012e84b/ACM2-25-e14180-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/354d8a3036b4/ACM2-25-e14180-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/72e3fdd2b897/ACM2-25-e14180-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/d3b36a16a027/ACM2-25-e14180-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/1b2bbe2e42db/ACM2-25-e14180-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/18d4949e32c6/ACM2-25-e14180-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/2173dde91e93/ACM2-25-e14180-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/c8be4012e84b/ACM2-25-e14180-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/354d8a3036b4/ACM2-25-e14180-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/72e3fdd2b897/ACM2-25-e14180-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/d3b36a16a027/ACM2-25-e14180-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/1b2bbe2e42db/ACM2-25-e14180-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/326c/10795437/18d4949e32c6/ACM2-25-e14180-g005.jpg

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