实时自适应磁共振引导放射治疗的技术挑战
Technical Challenges of Real-Time Adaptive MR-Guided Radiotherapy.
作者信息
Thorwarth Daniela, Low Daniel A
机构信息
Section for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Tübingen, Germany.
Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States.
出版信息
Front Oncol. 2021 Mar 8;11:634507. doi: 10.3389/fonc.2021.634507. eCollection 2021.
Abstract
In the past few years, radiotherapy (RT) has experienced a major technological innovation with the development of hybrid machines combining magnetic resonance (MR) imaging and linear accelerators. This new technology for MR-guided cancer treatment has the potential to revolutionize the field of adaptive RT due to the opportunity to provide high-resolution, real-time MR imaging before and during treatment application. However, from a technical point of view, several challenges remain which need to be tackled to ensure safe and robust real-time adaptive MR-guided RT delivery. In this manuscript, several technical challenges to MR-guided RT are discussed. Starting with magnetic field strength tradeoffs, the potential and limitations for purely MR-based RT workflows are discussed. Furthermore, the current status of real-time 3D MR imaging and its potential for real-time RT are summarized. Finally, the potential of quantitative MR imaging for future biological RT adaptation is highlighted.
摘要
在过去几年中，随着结合磁共振（MR）成像和直线加速器的混合机器的发展，放射治疗（RT）经历了重大的技术创新。这种用于MR引导癌症治疗的新技术有潜力彻底改变自适应放疗领域，因为它有机会在治疗实施前和治疗过程中提供高分辨率的实时MR成像。然而，从技术角度来看，仍存在一些挑战，需要加以解决以确保安全、稳健地进行实时自适应MR引导的放疗。在本手稿中，讨论了MR引导放疗的几个技术挑战。从磁场强度的权衡开始，讨论了基于纯MR的放疗工作流程的潜力和局限性。此外，总结了实时3D MR成像的现状及其在实时放疗中的潜力。最后，强调了定量MR成像在未来生物放疗适应方面的潜力。
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