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Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis Susceptibility.

作者信息

He Ming, Dong Jianjie, Wen Junmao, Zhang Yuqing, Han So Yun, Wang Chen, Gongol Brendan, Wei Tong-You Wade, Kang Jian, Huang Hsi-Yuan, Cheng Susan, Shyy John Y-J

机构信息

Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla (M.H., J.D., J.W., Y.Z., S.Y.H., B.G., T.-Y.W.W., J.K., J.Y-J.S.).

Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (C.W.).

出版信息

Circulation. 2023 Nov 28;148(22):1819-1822. doi: 10.1161/CIRCULATIONAHA.123.065455. Epub 2023 Nov 27.

Abstract
摘要

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microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production.
JCI Insight. 2020 Dec 3;5(23):143812. doi: 10.1172/jci.insight.143812.
2
Position-specific oxidation of miR-1 encodes cardiac hypertrophy.
Nature. 2020 Aug;584(7820):279-285. doi: 10.1038/s41586-020-2586-0. Epub 2020 Aug 5.
3
miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease.
Circ Res. 2017 Jan 20;120(2):354-365. doi: 10.1161/CIRCRESAHA.116.310233. Epub 2016 Dec 6.
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Oxidative Modification of miR-184 Enables It to Target Bcl-xL and Bcl-w.
Mol Cell. 2015 Jul 2;59(1):50-61. doi: 10.1016/j.molcel.2015.05.003. Epub 2015 May 28.
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RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.
J Neurosci. 1999 Mar 15;19(6):1959-64. doi: 10.1523/JNEUROSCI.19-06-01959.1999.

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