Ershadinia Nazanin, Mortazavinia Nader, Babaniamansour Sepideh, Najafi-Nesheli Mahdi, Babaniamansour Parto, Aliniagerdroudbari Ehsan
Department of Neurology, School of Medicine, Sari Branch, Islamic Azad University, Sari, Iran.
Department of Neurology, School of Medicine, Qom Branch, Islamic Azad University, Qom, Iran.
Curr J Neurol. 2020 Jul 5;19(3):98-102. doi: 10.18502/cjn.v19i3.5421.
Multiple sclerosis (MS) is one of the most common autoimmune diseases worldwide and various autoimmune comorbidities are reported with MS. The objective of this study is to estimate the prevalence of the autoimmune diseases' comorbidity in patients with MS. In this cross-sectional study, we investigated a group of patients with MS in terms of age, gender, duration of MS, presence of simultaneous autoimmune diseases, such as Graves' disease, Hashimoto's thyroiditis, type 1 diabetes mellitus (DM), and systemic lupus erythematous (SLE). This study included 1215 patients with MS, of which 70.8% were women. The mean age of participants was 33.70 ± 27.63 years. 55 patients (4.5%) had at least one autoimmune disease. The most common comorbidity was for Hashimoto's thyroiditis (30 patients). The frequency of simultaneous autoimmune disease was higher in women. Mean age (P = 0.01), mean duration of MS (P = 0.03), and mean age on MS diagnosis (P = 0.02) were significantly higher in simultaneous MS and other autoimmune diseases. Our study revealed that the probability of autoimmune diseases co-occurrence in patients with MS could be higher in older patients, in longer duration of disease, and also in patients with higher age at time of MS diagnosis.
多发性硬化症（MS）是全球最常见的自身免疫性疾病之一，且有多种自身免疫性合并症与MS相关。本研究的目的是评估MS患者中自身免疫性疾病合并症的患病率。在这项横断面研究中，我们从年龄、性别、MS病程、是否存在同时发生的自身免疫性疾病（如格雷夫斯病、桥本甲状腺炎、1型糖尿病（DM）和系统性红斑狼疮（SLE））等方面对一组MS患者进行了调查。本研究纳入了1215例MS患者，其中70.8%为女性。参与者的平均年龄为33.70±27.63岁。55例患者（4.5%）患有至少一种自身免疫性疾病。最常见的合并症是桥本甲状腺炎（30例患者）。女性同时发生自身免疫性疾病的频率更高。同时患有MS和其他自身免疫性疾病的患者，其平均年龄（P = 0.01）、MS平均病程（P = 0.03）以及MS诊断时的平均年龄（P = 0.02）均显著更高。我们的研究表明，MS患者中自身免疫性疾病同时发生的可能性在老年患者、病程较长的患者以及MS诊断时年龄较大的患者中可能更高。
