Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
BMC Urol. 2023 Nov 27;23(1):195. doi: 10.1186/s12894-023-01346-y.
Prior epidemiological observational studies have duly documented a correlative link between inflammatory bowel disease (IBD) and bladder cancer (BC); however, the establishment of a definitive causal relationship has remained elusive. The principal objective of this meticulous investigation was to rigorously evaluate the causal nexus between IBD and BC, employing the robust methodology of Mendelian randomization (MR) analysis.
We meticulously performed both univariate and multivariate Mendelian randomization (MVMR) analyses employing publicly accessible genome-wide association study (GWAS) data. The central approach employed for our investigations was inverse variance weighting (IVW) method, while diligently scrutinizing potential sources of heterogeneity and horizontal pleiotropy via the rigorous utilization of Cochran's Q test, the MR-PRESSO method, and MR-Egger.
In the univariate MR analysis, no causal link was observed between genetic prediction of IBD and BC. Furthermore, both Crohn's disease (CD) and ulcerative colitis (UC) showed no causal association with BC. The consistent association between CD and UC in the MVMR analysis supports this finding.
This study found no genetic basis for the causative association of IBD and BC. It is crucial to emphasize that further comprehensive investigations are warranted to delve into the intricate underlying mechanisms that may contribute to these associations.
先前的流行病学观察研究充分证明了炎症性肠病（IBD）和膀胱癌（BC）之间存在相关性；然而，确定其因果关系仍未可知。本研究旨在通过严谨的孟德尔随机化（MR）分析，严格评估 IBD 和 BC 之间的因果关系。
我们利用公开的全基因组关联研究（GWAS）数据，进行了单变量和多变量孟德尔随机化（MVMR）分析。研究中采用的主要方法是逆方差加权（IVW）法，同时通过严格的 Cochrane's Q 检验、MR-PRESSO 方法和 MR-Egger 方法，仔细检查了潜在的异质性和水平性 pleiotropy 来源。
在单变量 MR 分析中，IBD 的遗传预测与 BC 之间没有因果关系。此外，CD 和 UC 与 BC 之间也没有因果关联。MVMR 分析中 CD 和 UC 之间的一致性关联支持了这一发现。
本研究未发现 IBD 和 BC 之间存在因果关系的遗传基础。需要强调的是，进一步进行全面的研究以深入探讨可能导致这些关联的复杂潜在机制是至关重要的。
