丁硫氨酸亚砜胺与环磷酰胺对小鼠肿瘤和骨髓的联合作用。
Combined effect of buthionine sulfoximine and cyclophosphamide upon murine tumours and bone marrow.
作者信息
Ono K, Komuro C, Tsutsui K, Shibamoto Y, Nishidai T, Takahashi M, Abe M, Shrieve D C
出版信息
Br J Cancer. 1986 Nov;54(5):749-54. doi: 10.1038/bjc.1986.236.
Two and four treatments of 5 mmol kg-1 of buthionine sulfoximine (BSO) at an interval of 12 h depleted the glutathione (GSH) content in NFSa tumours of C3H/He mice, respectively, to 24.0 and 1.78 percent of the untreated controls. BSO pre-treatments every 12 h enhanced the cytotoxicity of cyclophosphamide (CYC) towards artificial lung micrometastases of NFSa tumours giving enhancement ratios (ERs) ranging from 1.75 to 1.83 and from 2.41 to 2.73, for two and four BSO pretreatments respectively. Large ERs were obtained at low CYC doses (high cell survival). Four BSO pre-treatments at an interval of 12 h did not increase the cytotoxicity of CYC to bone marrow stem cells. Our results suggest a clinical applicability of the combination of BSO and CYC.
以12小时的间隔进行两次和四次5 mmol kg-1的丁硫氨酸亚砜胺（BSO）处理，分别将C3H/He小鼠NFSa肿瘤中的谷胱甘肽（GSH）含量降至未处理对照的24.0%和1.78%。每12小时进行一次BSO预处理增强了环磷酰胺（CYC）对NFSa肿瘤人工肺微转移灶的细胞毒性，两次和四次BSO预处理的增强率（ER）分别为1.75至1.83和2.41至2.73。在低CYC剂量（高细胞存活率）下获得了较大的ER。以12小时的间隔进行四次BSO预处理并未增加CYC对骨髓干细胞的细胞毒性。我们的结果表明BSO和CYC联合使用具有临床应用价值。
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