Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité - Medical Heart Center of Charité and German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
DZHK (German Center for Cardiovascular Research) partner site Berlin, Berlin, Germany.
J Cardiothorac Surg. 2023 Nov 27;18(1):343. doi: 10.1186/s13019-023-02459-z.
Cardiogenic shock (CS) can occur in patients with Takotsubo syndrome (TTS). As TTS has received increasing attention and has been more closely researched, several aspects of the pathogenesis have been identified, particularly that an excessive release of catecholamines plays an important role. Nevertheless, evidence on specific therapy concepts is still lacking. As a result, TTS with severe hemodynamic instability and low cardiac output creates unique challenges, and mechanical circulatory support is needed with as few inotropic drugs as possible.
We present a 77-year-old female patient who underwent minimally invasive surgical mitral valve replacement. After an uneventful course, the patient developed acute heart failure eleven days after surgery. Transthoracic echocardiography (TTE) revealed a new onset of TTS. The patient needed left ventricular venting and full haemodynamic flow. We successfully implanted a microaxial left ventricular assist device (Impella 5.5) using the transaxillary approach. The haemodynamic situation stabilised immediately. The patient was weaned and the Impella 5.5 was explanted after five days.
We present the first-in-man implantation of a transaxillary Impella 5.5 in a patient with TTS. The patient benefitted from Impella 5.5 therapy with full haemodynamic support and venting of the left ventricle.
心尖球囊综合征(TTS)可并发心原性休克(CS)。随着 TTS 受到越来越多的关注和更深入的研究,其发病机制的几个方面已经确定,特别是儿茶酚胺的过度释放起着重要作用。然而,关于特定治疗概念的证据仍然缺乏。因此,伴有严重血流动力学不稳定和低心输出量的 TTS 带来了独特的挑战,需要使用尽可能少的正性肌力药物进行机械循环支持。
我们报告了一位 77 岁女性患者,她接受了微创二尖瓣置换术。术后恢复顺利,但在术后 11 天出现急性心力衰竭。经胸超声心动图(TTE)显示新发 TTS。患者需要左心室引流和完全血流动力学支持。我们成功地使用经腋入路植入了微型左心室辅助装置(Impella 5.5)。血流动力学情况立即稳定。患者成功脱机,五天后将 Impella 5.5 取出。
我们报告了首例 TTS 患者经腋入路植入 Impella 5.5。该患者接受了 Impella 5.5 治疗,充分的血流动力学支持和左心室引流使患者获益。