Kumar Aman, Abbas Daniyal, Barritt A Sidney, Lachiewicz Anne, Fix Oren K, Desai Chirag S
Department of Abdominal Transplant Surgery, UNC School of Medicine, Chapel Hill, United States.
Department of Medicine, East Carolina University, United States.
J Liver Transpl. 2023 May;10:100146. doi: 10.1016/j.liver.2023.100146. Epub 2023 Feb 24.
The COVID-19 pandemic has had a remarkable impact on the field of liver transplantation. Increasing evidence demonstrates a minimal risk of transmission of SARS-CoV-2 from non-lung donors who test positive for SARS-CoV-2; however, the risks of donor-derived SARS-CoV-2 from liver donors are unknown. We present our experience with two cases in which a liver was transplanted successfully from a brain-dead donor with incidental SARS-CoV-2 infection. Both donors were asymptomatic SARS-CoV-2-positive with negative bronchoalveolar lavage polymerase chain reaction (BAL PCR) and mechanism of death unrelated to COVID-19. Both the recipients did well after transplant and went home with a well-functioning liver. One patient did get readmitted and was found to be SARS-CoV-2-positive; however, it was probably related to hospital exposure rather than donor-derived. SARS-CoV-2-positive donors in select cases may be used for organ donation and liver transplant is safe for recipients.
新冠疫情对肝移植领域产生了显著影响。越来越多的证据表明，新冠病毒检测呈阳性的非肺供体传播新冠病毒的风险极小；然而，肝供体来源的新冠病毒风险尚不清楚。我们介绍了两例成功从伴有偶发性新冠病毒感染的脑死亡供体移植肝脏的经验。两名供体均为无症状新冠病毒阳性，支气管肺泡灌洗聚合酶链反应（BAL PCR）呈阴性，死亡机制与新冠病毒无关。两名受者移植后情况良好，带着功能良好的肝脏回家。一名患者再次入院，被发现新冠病毒呈阳性；然而，这可能与医院接触有关，而非供体来源。在某些情况下，新冠病毒阳性供体可用于器官捐赠，肝移植对受者是安全的。
