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STX3 转录本和蛋白水平的升高与两个独立的食管鳞癌患者队列的不良预后相关。

Increased STX3 transcript and protein levels were associated with poor prognosis in two independent cohorts of esophageal squamous cell carcinoma patients.

机构信息

Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Department of Thoracic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

出版信息

Cancer Med. 2023 Dec;12(24):22185-22195. doi: 10.1002/cam4.6770. Epub 2023 Nov 28.

DOI:10.1002/cam4.6770
PMID:38014487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10757105/
Abstract

BACKGROUND

Some conventional prognostic biomarkers for esophageal squamous cell carcinoma (ESCC) have the disadvantage that they have only been investigated at the level of either mRNA or protein levels or only in individual cohorts. Associations between Syntaxin 3 (STX3) expression and malignancy have been reported in several tumor types but not in ESCC. Here, we investigated the levels of both STX3 mRNA and protein, and its prognostic potential in two independent cohorts of patients with ESCC.

METHODS

STX3 mRNA levels were examined in surgical specimens by quantitative PCR in a cohort that included 176 ESCC patients. STX3 protein levels were investigated in surgically resected ESCC tissues by immunohistochemistry using tissue microarrays in a different cohort of 177 ESCC patients. Correlations were analyzed between the expression of STX3 mRNA and protein with clinicopathological factors and long-term prognosis.

RESULTS

Quantitative PCR indicated a significant association between high level of STX3 mRNA expression and lymph node involvement, pathological stage, and poor overall survival. The multivariate analysis demonstrated that high STX3 mRNA expression was independently associated with poor overall survival outcomes. Immunohistochemistry revealed that STX3 protein expression in ESCC tissues and high STX3 protein expression were also significantly correlated with unfavorable overall survival.

CONCLUSIONS

Overexpression of STX3 mRNA and protein may serve as potential prognostic biomarkers for ESCC patients.

摘要

背景

一些传统的食管鳞癌（ESCC）预后生物标志物的缺点在于，它们仅在 mRNA 或蛋白质水平上进行了研究，或者仅在单个队列中进行了研究。在几种肿瘤类型中已经报道了 Syntaxin 3（STX3）表达与恶性肿瘤之间的相关性，但在 ESCC 中尚未报道。在这里，我们研究了两个独立的 ESCC 患者队列中 STX3 mRNA 和蛋白的水平及其预后潜力。

方法

在包括 176 名 ESCC 患者的队列中，通过定量 PCR 检查了 STX3 mRNA 水平。在另一个包括 177 名 ESCC 患者的队列中，通过使用组织微阵列的免疫组织化学方法研究了 STX3 蛋白水平。分析了 STX3 mRNA 和蛋白表达与临床病理因素和长期预后之间的相关性。

结果

定量 PCR 表明 STX3 mRNA 表达水平高与淋巴结受累、病理分期和总体生存率差之间存在显著相关性。多变量分析表明，高 STX3 mRNA 表达与总体生存率不良独立相关。免疫组织化学显示，ESCC 组织中 STX3 蛋白表达和高 STX3 蛋白表达也与总体生存率不良显著相关。

结论

STX3 mRNA 和蛋白的过表达可能成为 ESCC 患者潜在的预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dd4/10757105/0e9e955e1473/CAM4-12-22185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dd4/10757105/c8a136ca0f4c/CAM4-12-22185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dd4/10757105/0e9e955e1473/CAM4-12-22185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dd4/10757105/c8a136ca0f4c/CAM4-12-22185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dd4/10757105/0e9e955e1473/CAM4-12-22185-g001.jpg

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