Hu Chengxian, Wang Lu, Wu Yuanyuan, Zheng Yonglong, Fu Ying, Du Zhengyin
Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, P. R. China.
Chem Commun (Camb). 2023 Dec 14;59(100):14839-14842. doi: 10.1039/d3cc04534j.
A novel Pd-catalyzed assembly of -substituted phthalimides by merging of [4+1] cycloaddition and difluorocarbene transfer carbonylation from 2-iodo--phenylbenzamides and difluorocarbene precursors is disclosed. Difluorocarbene acts as a carbonyl source and simultaneously forms one C-C bond, one C-N bond and one CO bond to produce -substituted phthalimides in high yields.
公开了一种通过将[4+1]环加成与来自2-碘-α-苯基苯甲酰胺和二氟卡宾前体的二氟卡宾转移羰基化反应相结合，实现钯催化的α-取代邻苯二甲酰亚胺的新型合成方法。二氟卡宾作为羰基源，同时形成一个C-C键、一个C-N键和一个C=O键，以高产率生成α-取代邻苯二甲酰亚胺。
