Synthesis of 1,3,4-oxadiazoles with 4-methoxynaphthalene ring: discovering new compounds with antimicrobial activity.

Paracoccidioidomycosis (PCM) is a systemic infection caused by spp. (). PCM can be associated or clinically confused with tuberculosis (TB), another pulmonary infection, caused by (). Futhermore, the long treatment time of TB and PCM and the cases of TB drug resistance impose difficulties for the cure of these diseases. New 1,3,4-oxadiazoles containing the 4-methoxynaphthalene ring were synthesized and their antimicrobial activity was evaluated against and . The derivative (with 2-hydroxy-5-nitrophenyl subunit) is the most promising of the series. The 1,3,4-oxadiazole can be used as a prototype drug candidate, with anti- and anti- activities, showing a broad-spectrum profile for the treatment of both pulmonary infections.