A new -acylhydrazone oxadiazole derivative with activity against mycobacteria.

To evaluate the anti () potential of the hybrid oxadiazol-4-methoxynaphthalene () derived from -acylhydrazone (). The study determined the minimal inhibitory concentration of ( against HRv and clinical isolates, potential combination of ( with anti-tuberculosis drugs and carried out time kill curve assay of HRv. Additional contribution for the analysis of was explored by pharmacokinetics, and and cytotoxicity determinations. The newly synthesized molecule ( demonstrated anti- activity, low cytotoxicity and selectivity for The derivative () emerges as a potential anti-TB drug candidate.