Hôpital Universitaire Bicêtre, Le Kremlin-Bicêtre, France.
Becton, Dickinson and Company, Franklin Lakes, NJ, USA.
Ann Pharmacother. 2024 Sep;58(9):921-934. doi: 10.1177/10600280231212890. Epub 2023 Nov 28.
The objective of this systematic review was to assess the clinical, economic, and health resource utilization outcomes associated with the use of prefilled syringes in medication administration compared with traditional preparation methods.
We conducted a systematic literature review to evaluate outcomes such as medication errors, wastage, time savings, and contamination in prefilled syringes. Our search encompassed multiple databases, including PubMed and Embase, for studies published between January 1, 2017, and November 1, 2022.
Peer-reviewed publications meeting our inclusion criteria underwent rigorous screening, including title, abstract, and full-text article assessments, performed by two reviewers.
Among reviewed articles, 24 met our eligibility criteria. Selected studies were primarily observational (46%) and conducted in Europe (46%). Our findings indicated that prefilled syringes consistently reduced medication errors (by 10%-73%), adverse events (from 1.1 to 0.275 per 100 administrations), wastage (by up to 80% of drug), and preparation time (from 4.0 to 338.0 seconds) (ranges varied by drug type, setting, and dosage). However, there was limited data on contamination. Economically, prefilled syringes reduced waste and error rates, which may translate into overall savings.
This review highlights the value of prefilled syringes, which can streamline medication delivery, save nursing time, and reduce preventable medication errors. Moreover, prefilled syringes have the potential to minimize medication wastage, optimizing resource utilization and efficiency in health care settings.
Our findings provide new insights into clinical and economic benefits of prefilled syringe adoption. These benefits include improved medication delivery and safety, which can lead to time and cost reductions for health care departments, hospitals, and health systems. However, further real-world research on clinical and economic outcomes, especially in contamination, is needed to better understand the benefits of prefilled syringes.
本系统评价的目的是评估与传统准备方法相比，在给药中使用预充注射器与临床、经济和卫生资源利用结果相关联。
我们进行了系统文献检索，以评估药物错误、浪费、节省时间和预充注射器污染等结果。我们的搜索涵盖了多个数据库，包括 PubMed 和 Embase，检索时间为 2017 年 1 月 1 日至 2022 年 11 月 1 日期间发表的研究。
符合纳入标准的同行评审出版物经过严格筛选，包括两名评审员进行的标题、摘要和全文文章评估。
在审查的文章中，有 24 篇符合我们的入选标准。选定的研究主要是观察性的（46%），并在欧洲进行（46%）。我们的研究结果表明，预充注射器可一致减少药物错误（减少 10%-73%）、不良事件（每 100 次给药从 1.1 减少到 0.275）、浪费（高达 80%的药物）和准备时间（从 4.0 秒减少到 338.0 秒）（药物类型、设置和剂量不同，范围也不同）。然而，关于污染的数据有限。从经济角度来看，预充注射器减少了浪费和错误率，这可能转化为总体节省。
本综述强调了预充注射器的价值，它可以简化药物输送，节省护理时间，并减少可预防的药物错误。此外，预充注射器有可能最大限度地减少药物浪费，优化医疗保健环境中的资源利用和效率。
我们的研究结果提供了采用预充注射器的临床和经济效益的新见解。这些好处包括改善药物输送和安全性，从而为医疗保健部门、医院和医疗保健系统节省时间和成本。然而，需要进一步开展关于临床和经济结果，特别是污染的真实世界研究，以更好地了解预充注射器的益处。
