Department of Health and Physical Activity, Institute III, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
University of Applied Sciences for Sport and Management Potsdam, Potsdam, Germany.
Transl Vis Sci Technol. 2023 Nov 1;12(11):31. doi: 10.1167/tvst.12.11.31.
To investigate gait kinematics during single- and dual-task walking in glaucoma patients compared with healthy controls.
Nineteen glaucoma patients (10 females, 9 males) and 30 healthy controls (17 females, 13 males) participated in this cross-sectional study. Spatiotemporal gait parameters (e.g., stride length, velocity, minimum toe clearance [MTC]) were assessed using inertial measurement units (sampling frequency 100 Hz) during single-task walking and dual-task walking at a comfortable velocity. During dual-task walking, participants walked and concurrently performed different cognitive tasks in a random order: (i) reaction time task, (ii) N-Back-task, and (iii) letter fluency task with two difficulty levels, respectively. Repeated measures analyses of covariance (Group × Condition) were conducted to analyze the data.
A significant effect of group was found for the coefficient of variation (CoV) of the MTC, F(1,39) = 4.504, P = 0.040, ({\rm{\eta }}{\rm{p}}^2) = 0.104, with higher values in glaucoma patients. Based on the effect sizes, a main effect of group was also found for the MTC, F(1,39) = 2.668, P = 0.110, ({\rm{\eta }}{\rm{p}}^2) = 0.064, and the MTCCoV dual-task costs, F(1,38) = 3.225, P = 0.08, ({\rm{\eta }}_{\rm{p}}^2) = 0.078, which was lower and higher, respectively, in glaucoma patients.
The present study revealed a significantly higher MTC variability as well as medium effect sizes for a lower MTC and higher MTC dual-task costs in glaucoma patients compared with healthy controls, which might be related to a higher risk of falling owing to tripping.
The minimum toe clearance might mirror disease-related changes in walking performance and might have prognostic value for assessing fall risk in glaucoma patients.
研究与健康对照组相比，青光眼患者在单任务和双任务行走时的步态运动学。
本横断面研究纳入了 19 名青光眼患者（10 名女性，9 名男性）和 30 名健康对照者（17 名女性，13 名男性）。使用惯性测量单元（采样频率 100 Hz）评估单任务行走和双任务行走（以舒适速度）时的时空步态参数（例如步长、速度、最小脚趾间隙[MTC]）。在双任务行走中，参与者以随机顺序同时执行不同的认知任务：（i）反应时间任务，（ii）N 回任务，和（iii）字母流畅性任务，难度级别分别为两个。采用协方差重复测量分析（组×条件）对数据进行分析。
组间变异系数（CoV）的 MTC 存在显著的组间效应，F(1,39) = 4.504，P = 0.040，({\rm{\eta }}{\rm{p}}^2) = 0.104，青光眼患者的 CoV 值更高。根据效应大小，MTC 也存在显著的组间效应，F(1,39) = 2.668，P = 0.110，({\rm{\eta }}{\rm{p}}^2) = 0.064，以及 MTCCoV 双任务成本，F(1,38) = 3.225，P = 0.08，({\rm{\eta }}_{\rm{p}}^2) = 0.078，青光眼患者的 MTCCoV 双任务成本更低，而 MTC 更高。
与健康对照组相比，本研究发现青光眼患者的 MTC 变异性显著更高，MTC 更低，MTC 双任务成本更高，这可能与因绊倒而导致更高的跌倒风险有关。
医学 科研
