Laudignon N, Chemtob S, Beharry K, Rex J, Aranda J V
Biol Neonate. 1986;50(5):288-96. doi: 10.1159/000242611.
Heart rate, cardiac output, mean arterial blood pressure (MABP), and cerebral blood flow (CBF) were measured in 12 newborn piglets (6 controls and 6 pretreated with 20 mg/kg phenobarbital), under two different stresses: pain stimulation and intravenous injection of 2.5 mg/kg phenylephrine. Phenobarbital prevented pain-induced tachycardia (p less than 0.05 versus controls) but failed to prevent hemodynamic changes induced by phenylephrine. CBF remained relatively constant throughout the study. A better correlation between cerebral vascular resistance and MABP was noted in the phenobarbital group (r = 0.58, p less than 0.01) than in the controls (r = 0.15, p = NS), suggesting that phenobarbital potentiates the vasoconstrictor effect of catecholamines.
在12只新生仔猪（6只对照，6只预先用20mg/kg苯巴比妥处理）中，于两种不同应激状态下测量心率、心输出量、平均动脉血压（MABP）和脑血流量（CBF）：疼痛刺激和静脉注射2.5mg/kg去氧肾上腺素。苯巴比妥可预防疼痛诱导的心动过速（与对照组相比，p<0.05），但未能预防去氧肾上腺素诱导的血流动力学变化。在整个研究过程中，CBF保持相对恒定。与对照组（r = 0.15，p =无显著性差异）相比，苯巴比妥组脑血管阻力与MABP之间的相关性更好（r = 0.58，p<0.01），提示苯巴比妥可增强儿茶酚胺的血管收缩作用。
