Department of Orthopedics, Sinopharm China Railway Engineering Corporation Central Hospital, Hefei, China.
Physiol Res. 2023 Nov 28;72(5):565-574. doi: 10.33549/physiolres.935143.
Fracture healing is a multifaceted process that requires various phases and intercellular interactions. In recent years, investigations have been conducted to assess the feasibility of utilizing exosomes, small extracellular vesicles (EVs), to enhance and accelerate the healing process. Exosomes serve as a cargo transport platform, facilitating intercellular communication, promoting the presentation of antigens to dendritic cells, and stimulating angiogenesis. Exosomes have a special structure that gives them a special function, especially in the healing process of bone injuries. This article provides an overview of cellular and molecular processes associated with bone fracture healing, as well as a survey of existing exosome research in this context. We also discuss the potential use of exosomes in fracture healing, as well as the obstacles that must be overcome to make this a viable clinical practice.
骨折愈合是一个多方面的过程，需要多个阶段和细胞间的相互作用。近年来，已经进行了研究来评估利用外泌体，即小细胞外囊泡（EVs）来增强和加速愈合过程的可行性。外泌体充当货物运输平台，促进细胞间的通讯，促进抗原呈递给树突状细胞，并刺激血管生成。外泌体具有特殊的结构，赋予它们特殊的功能，特别是在骨损伤的愈合过程中。本文概述了与骨骨折愈合相关的细胞和分子过程，并对这方面的现有外泌体研究进行了调查。我们还讨论了外泌体在骨折愈合中的潜在用途，以及为了使其成为可行的临床实践而必须克服的障碍。
