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SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis.

作者信息

Sui Pinpin, Ge Guo, Chen Shi, Bai Jiaojiao, Rubalcava Ivan P, Yang Hui, Guo Ying, Zhang Peng, Li Ying, Medina Edward A, Xu Mingjiang, Abdel-Wahab Omar, Bradley Robert, Yang Feng-Chun

机构信息

Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

出版信息

Leukemia. 2024 Feb;38(2):408-411. doi: 10.1038/s41375-023-02094-6. Epub 2023 Nov 28.

DOI:10.1038/s41375-023-02094-6
PMID:38017104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10844088/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fc2/10844088/fad959374cfd/41375_2023_2094_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fc2/10844088/26e40f0f645a/41375_2023_2094_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fc2/10844088/fad959374cfd/41375_2023_2094_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fc2/10844088/26e40f0f645a/41375_2023_2094_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fc2/10844088/fad959374cfd/41375_2023_2094_Fig2_HTML.jpg

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本文引用的文献

1
Molecular International Prognostic Scoring System for Myelodysplastic Syndromes.骨髓增生异常综合征的分子国际预后评分系统
NEJM Evid. 2022 Jul;1(7):EVIDoa2200008. doi: 10.1056/EVIDoa2200008. Epub 2022 Jun 12.
2
Acute Myeloid Leukemia with Co-mutated and Exhibits Monocytic Differentiation and has a Mutational Profile Overlapping with Chronic Myelomonocytic Leukemia.伴有共同突变且表现出单核细胞分化的急性髓系白血病,其突变谱与慢性粒单核细胞白血病重叠。
Hemasphere. 2019 Sep 11;3(4):e292. doi: 10.1097/HS9.0000000000000292. eCollection 2019 Oct.
3
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.
ASXL1 截断蛋白功能获得在髓系恶性肿瘤发病机制中的作用。
Blood. 2018 Jan 18;131(3):328-341. doi: 10.1182/blood-2017-06-789669. Epub 2017 Nov 7.
4
Genomic Classification and Prognosis in Acute Myeloid Leukemia.急性髓系白血病的基因组分类与预后
N Engl J Med. 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192.
5
The genomic landscape of juvenile myelomonocytic leukemia.青少年粒单核细胞白血病的基因组格局
Nat Genet. 2015 Nov;47(11):1326-1333. doi: 10.1038/ng.3400. Epub 2015 Oct 12.
6
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.SRSF2突变通过对外显子识别的突变特异性影响导致骨髓增生异常。
Cancer Cell. 2015 May 11;27(5):617-30. doi: 10.1016/j.ccell.2015.04.006.
7
Dynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome.原发性骨髓增生异常综合征患者疾病进展过程中 ASXL1 突变及其他相关遗传改变的动态变化。
Blood Cancer J. 2014 Jan 17;4(1):e177. doi: 10.1038/bcj.2013.74.
8
Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms.骨髓增殖性肿瘤中 ASXL1、CBL、DNMT3A、IDH1、IDH2、JAK2、MPL、NF1、SF3B1、SUZ12 和 TET2 的突变分析。
Genes Chromosomes Cancer. 2012 Aug;51(8):743-55. doi: 10.1002/gcc.21960. Epub 2012 Apr 9.
9
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.急性髓系白血病中综合基因分析的预后相关性。
N Engl J Med. 2012 Mar 22;366(12):1079-89. doi: 10.1056/NEJMoa1112304. Epub 2012 Mar 14.
10
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Blood. 2012 Apr 12;119(15):3578-84. doi: 10.1182/blood-2011-12-399337. Epub 2012 Mar 2.