COVID-19 与子痫前期/子痫之间的遗传易感性：一项孟德尔随机化研究。

Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study.

机构信息

Department of Public Health Response, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.

出版信息

Hypertens Pregnancy. 2023 Dec;42(1):2285757. doi: 10.1080/10641955.2023.2285757. Epub 2023 Nov 28.

DOI:10.1080/10641955.2023.2285757

PMID:38017693

Abstract

OBJECTIVE

The aim of this study was to investigate the possible causal relationship between COVID-19 and the risk of pre-eclampsia/eclampsia using a Mendelian randomized (MR) design.

METHODS

We estimated their genetic correlations and then performed two-sample Mendelian randomization analyses using pooled statistics from the COVID-19 susceptibility/hospitalization genome-wide association study and the pre-eclampsia/eclampsia datasets. The main analyses were performed using the inverse variance weighting method, supplemented by the weighted median method and the MR-Egger method.

RESULTS

We identified a significant and positive genetic correlation between COVID-19 susceptibility and pre-eclampsia/eclampsia [OR = 1.23 (1.01-1.51), = 0.043]. Meanwhile, hospitalization of COVID-19 was significantly associated with a higher risk of pre-eclampsia/eclampsia [OR = 1.15 (1.02-1.30), = 0.024]. Consistently, hospitalization of COVID-19 were nominally associated with higher risk of pre-eclampsia [OR = 1.14, (1.01-1.30), = 0.040]. The results were robust under all sensitivity analyses.

CONCLUSION

These results suggest that COVID-19 may increase the risk of pre-eclampsia/eclampsia. Future development of preventive or therapeutic interventions should emphasize this to mitigate the complications of COVID-19. [Figure: see text].

摘要

目的

本研究旨在使用孟德尔随机化（MR）设计来探究 COVID-19 与子痫前期/子痫风险之间的可能因果关系。

方法

我们估计了它们的遗传相关性，然后使用 COVID-19 易感性/住院全基因组关联研究和子痫前期/子痫数据集的汇总统计数据进行两样本 Mendelian 随机化分析。主要分析采用逆方差加权法进行，同时补充加权中位数法和 MR-Egger 法。

结果

我们发现 COVID-19 易感性与子痫前期/子痫之间存在显著正遗传相关性[OR=1.23（1.01-1.51），P=0.043]。同时，COVID-19 的住院与子痫前期/子痫的风险升高显著相关[OR=1.15（1.02-1.30），P=0.024]。一致地，COVID-19 的住院与子痫前期的风险升高具有统计学意义[OR=1.14（1.01-1.30），P=0.040]。所有敏感性分析结果均稳健。