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嗅球切除术可预防毛果芸香碱诱导的大鼠肢体边缘性运动性癫痫发作。

Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats.

作者信息

Millan M H, Patel S, Meldrum B S

出版信息

Brain Res. 1986 Nov 19;398(1):204-6. doi: 10.1016/0006-8993(86)91271-0.

DOI:10.1016/0006-8993(86)91271-0
PMID:3801895
Abstract

Systemic injection of pilocarpine (380 mg/kg) results in the development of motor limbic seizures in rats. Olfactory bulbectomy performed 7 days prior to pilocarpine administration has a strong protective effect against the seizures. Neuropathological changes which normally occur in this seizure model do not develop in the brains of bulbectomized animals.

摘要

全身注射毛果芸香碱(380毫克/千克)会导致大鼠出现运动性边缘叶癫痫发作。在给予毛果芸香碱前7天进行嗅球切除术对癫痫发作有很强的保护作用。在该癫痫模型中通常出现的神经病理学变化在嗅球切除动物的大脑中不会发生。

相似文献

1
Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats.嗅球切除术可预防毛果芸香碱诱导的大鼠肢体边缘性运动性癫痫发作。
Brain Res. 1986 Nov 19;398(1):204-6. doi: 10.1016/0006-8993(86)91271-0.
2
Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study.毛果芸香碱诱发大鼠边缘叶癫痫发作:行为学、脑电图及神经病理学研究
Behav Brain Res. 1983 Sep;9(3):315-35. doi: 10.1016/0166-4328(83)90136-5.
3
Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats.向大鼠梨状前皮质局部注射2-氨基-7-磷酸庚酸可预防匹鲁卡品诱导的边缘叶癫痫发作。
Neurosci Lett. 1986 Sep 25;70(1):69-74. doi: 10.1016/0304-3940(86)90439-8.
4
The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats.
Exp Brain Res. 1988;72(3):517-22. doi: 10.1007/BF00250597.
5
Conditioned taste aversion is reduced in rats with a history of lithium/pilocarpine-induced limbic seizures.在有锂/毛果芸香碱诱导的边缘系统癫痫病史的大鼠中,条件性味觉厌恶反应减弱。
Neurosci Lett. 1988 Jul 19;90(1-2):177-80. doi: 10.1016/0304-3940(88)90807-5.
6
The vital dye Evans blue mimics limbic seizures induced by kainate or pilocarpine.活性染料伊文思蓝可模拟由海藻酸或毛果芸香碱诱发的边缘叶癫痫发作。
Brain Res. 1997 Apr 11;753(2):283-90. doi: 10.1016/s0006-8993(97)00032-2.
7
The susceptibility of rats to pilocarpine-induced seizures is age-dependent.大鼠对毛果芸香碱诱导的癫痫发作的易感性具有年龄依赖性。
Brain Res. 1987 Dec 15;465(1-2):43-58. doi: 10.1016/0165-3806(87)90227-6.
8
The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures.锂-毛果芸香碱和高剂量毛果芸香碱诱发癫痫发作的功能解剖学与病理学
Neuroscience. 1987 Dec;23(3):953-68. doi: 10.1016/0306-4522(87)90171-0.
9
Similar increases in extracellular lactic acid in the limbic system during epileptic and/or olfactory stimulation.在癫痫发作和/或嗅觉刺激期间,边缘系统细胞外乳酸有类似的增加。
Neuroscience. 2000;97(3):447-58. doi: 10.1016/s0306-4522(00)00038-5.
10
The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions.大鼠自发性癫痫发作的频率与感觉运动门控、空间工作记忆以及整个边缘区域小白蛋白表达的改变相关。
Neuroscience. 2016 Jan 15;312:86-98. doi: 10.1016/j.neuroscience.2015.11.008. Epub 2015 Nov 12.

引用本文的文献

1
Olfactory Bulbectomy Leads to the Development of Epilepsy in Mice.嗅球切除术导致小鼠癫痫的发生。
PLoS One. 2015 Sep 14;10(9):e0138178. doi: 10.1371/journal.pone.0138178. eCollection 2015.
2
Neuronal and glial cell populations in the piriform cortex distinguished by using an approximation of q-space imaging after status epilepticus.癫痫持续状态后,通过使用q空间成像近似法区分梨状皮质中的神经元和神经胶质细胞群。
AJNR Am J Neuroradiol. 2004 Aug;25(7):1225-33.
3
Rapid alterations in diffusion-weighted images with anatomic correlates in a rodent model of status epilepticus.
癫痫持续状态啮齿动物模型中扩散加权图像的快速改变及其解剖学关联
AJNR Am J Neuroradiol. 2000 Nov-Dec;21(10):1841-52.
4
The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats.
Exp Brain Res. 1988;72(3):517-22. doi: 10.1007/BF00250597.