嗅球切除术可预防毛果芸香碱诱导的大鼠肢体边缘性运动性癫痫发作。
Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats.
作者信息
Millan M H, Patel S, Meldrum B S
出版信息
Brain Res. 1986 Nov 19;398(1):204-6. doi: 10.1016/0006-8993(86)91271-0.
PMID:3801895
Abstract
Systemic injection of pilocarpine (380 mg/kg) results in the development of motor limbic seizures in rats. Olfactory bulbectomy performed 7 days prior to pilocarpine administration has a strong protective effect against the seizures. Neuropathological changes which normally occur in this seizure model do not develop in the brains of bulbectomized animals.
摘要
全身注射毛果芸香碱（380毫克/千克）会导致大鼠出现运动性边缘叶癫痫发作。在给予毛果芸香碱前7天进行嗅球切除术对癫痫发作有很强的保护作用。在该癫痫模型中通常出现的神经病理学变化在嗅球切除动物的大脑中不会发生。
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